1. NF-κB
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  3. BIZ 114

BIZ 114 

Cat. No.: HY-135808
Handling Instructions

BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases.

For research use only. We do not sell to patients.

BIZ 114 Chemical Structure

BIZ 114 Chemical Structure

CAS No. : 2099120-74-6

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Description

BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases[1].

IC50 & Target

NF-κΒ[1]

In Vitro

Polyunsaturated fatty acids and their metabolites are involved in many physiological and pathophysiological reactions and as such possess a range of important biological activities. They affect plasma lipids and lipid metabolism. They are incorporated into cell membranes where they influence different cell functions. They are also involved in inflammatory diseases and they also influence and control gene expression. The fatty acid derivatives have the potential for treatment and/or prevention of ophthalmic disorders, in particular retinal disorders such as age-related macular degeneration and diabetic retinopathy, and ocular inflammatory diseases[1].

Molecular Weight

376.57

Formula

C₂₄H₄₀O₃

CAS No.

2099120-74-6

SMILES

CCC(OCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BIZ 114BIZ114BIZ-114NF-κBNuclear factor-κBNuclear factor-kappaBTNF-αF-κΒanti-inflammatorymitochondrialpolyunsaturatedfattyacidsophthalmicdisordersInhibitorinhibitorinhibit

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BIZ 114
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