1. NF-κB
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  3. BIZ 114

BIZ 114 

Cat. No.: HY-135808 Purity: ≥98.0%
Handling Instructions

BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases.

For research use only. We do not sell to patients.

BIZ 114 Chemical Structure

BIZ 114 Chemical Structure

CAS No. : 2099120-74-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 226 In-stock
Estimated Time of Arrival: December 31
Liquid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 226 In-stock
Estimated Time of Arrival: December 31
Liquid
10 mg USD 205 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activated NF-κΒ pathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and ocular inflammatory diseases[1].

IC50 & Target

NF-κΒ[1]

In Vitro

Polyunsaturated fatty acids and their metabolites are involved in many physiological and pathophysiological reactions and as such possess a range of important biological activities. They affect plasma lipids and lipid metabolism. They are incorporated into cell membranes where they influence different cell functions. They are also involved in inflammatory diseases and they also influence and control gene expression. The fatty acid derivatives have the potential for treatment and/or prevention of ophthalmic disorders, in particular retinal disorders such as age-related macular degeneration and diabetic retinopathy, and ocular inflammatory diseases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

376.57

Formula

C₂₄H₄₀O₃

CAS No.
SMILES

CCC(OCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (663.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6555 mL 13.2777 mL 26.5555 mL
5 mM 0.5311 mL 2.6555 mL 5.3111 mL
10 mM 0.2656 mL 1.3278 mL 2.6555 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.33 mg/mL (6.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.33 mg/mL (6.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

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Keywords:

BIZ 114BIZ114BIZ-114NF-κBNuclear factor-κBNuclear factor-kappaBTNF-αF-κΒanti-inflammatorymitochondrialpolyunsaturatedfattyacidsophthalmicdisordersInhibitorinhibitorinhibit

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BIZ 114
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HY-135808
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