1. Epigenetics
    TGF-beta/Smad
    Apoptosis
    Autophagy
  2. PKC
    Bcl-2 Family
    Apoptosis
    Autophagy
  3. Chelerythrine

Chelerythrine 

Cat. No.: HY-N2359
Handling Instructions

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.

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Chelerythrine Chemical Structure

Chelerythrine Chemical Structure

CAS No. : 34316-15-9

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Description

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy[3][4].

IC50 & Target[1]

PKC

0.7 μM (IC50)

Molecular Weight

348.37

Formula

C₂₁H₁₈NO₄

CAS No.

34316-15-9

SMILES

C[N+]1=CC2=C(OC)C(OC)=CC=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ChelerythrinePKCBcl-2 FamilyApoptosisAutophagyProtein kinase CInhibitorinhibitorinhibit

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