1. Epigenetics
    TGF-beta/Smad
    Apoptosis
    Autophagy
  2. PKC
    Bcl-2 Family
    Apoptosis
    Autophagy
  3. Chelerythrine

Chelerythrine 

Cat. No.: HY-N2359
Handling Instructions

Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy.

For research use only. We do not sell to patients.

Chelerythrine Chemical Structure

Chelerythrine Chemical Structure

CAS No. : 34316-15-9

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Top Publications Citing Use of Products

    Chelerythrine purchased from MCE. Usage Cited in: Sci Rep. 2017 Aug 23;7(1):9201.

    CGP3466B upregulates PCMT1 expression and inhibits cleaved-Mst1 activation at 24 h after TBI. Chelerythrine activates the Mst1 without regulating PCMT1 protein level. (a) Western blot assay for the expression of PCMT1. (b) Western blot assay for the expression of Mst1 and cleaved-Mst1.
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    Description

    Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2]. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy[3][4].

    IC50 & Target[1]

    PKC

    0.7 μM (IC50)

    Molecular Weight

    348.37

    Formula

    C₂₁H₁₈NO₄

    CAS No.

    34316-15-9

    SMILES

    C[N+]1=CC2=C(OC)C(OC)=CC=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5

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    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Keywords:

    ChelerythrinePKCBcl-2 FamilyApoptosisAutophagyProtein kinase CInhibitorinhibitorinhibit

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