Chelerythrine hydroxide
Based on 8 publication(s) in Google Scholar
Chelerythrine hydroxide is an alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine hydroxide inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM. Chelerythrine hydroxide triggers Apoptosis and Autophagy. Chelerythrine hydroxide has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine hydroxide shows antibacterial activities against Gram-positive bacteria, Staphylococcus aureus (SA), MRSA.
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- CAS. Nr.: 478-03-5
- Formel: C21H19NO5
- Molecular Weight:365.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Chelerythrine hydroxide
More- Cell Commun Signal. 2021 Oct 11;19(1):103. [Abstract]
- Cancer Cell Int. 2023 Jun 17;23(1):117. [Abstract]
- Front Pharmacol. 2021 May 13:12:655726. [Abstract]
- Front Physiol. 2021 Oct 28;12:770430. [Abstract]
- FASEB J. 2019 Dec;33(12):13644-13659. [Abstract]
- Fishes. 2022, 7(5), 229.
- Biochem Biophys Res Commun. 2024 Oct 29:739:150914. [Abstract]
- Planta Med. 2024 Jun;90(7-08):523-533. [Abstract]
Biologische Aktivität
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PKC 0.7 μM (IC50) |
Bcl-xL |
Chelerythrine (48 h) hydroxide inhibits the growth of L-1210 cells (IC50: 0.53 uM )[1].
Chelerythrine (0-20 μM, 24 h) hydroxide inhibits cell viability, induces apoptosis and autophagy in A549 and NCI-H1299 cells[4].
Chelerythrine (0-5 μM, 24 or 48 h) hydroxide induces apoptosis in BclXL-overexpressing SH-SY5Y cells[3].
Chelerythrine (2.5-10 μM, 16 h) hydroxide induces mitochondrial depolarization (decrease in mitochondrial potential) in SH-SY5Y cells, and stimulates release of CytC from isolated mitochondria[4].
Chelerythrine (0-100 ng/mL, 24 h) hydroxide reduces the LPS induced production of NO and TNF-α in primary macrophages[5].
Chelerythrine (MIC: 0.156 mg/mL) hydroxide shows antibacterial activities against Gram-positive bacteria, Staphylococcus aureus (SA), MRSA, and extended spectrum β-lactamase S. aureus (ESBLs-SA)[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 and NCI-H1299 cells
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Concentration:10, 15, 20 μM
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Incubation Time:24 h
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Result:Induced expression of LC3-II in a beclin 1-dependent way.
Chelerythrine (1-10 mg/kg, i.p., at 24 and 1 h before injection of 100 μg/kg LPS) hydroxide shows anti-inflammatory effects (increased survival rate, decreased serum nitrite and TNF-α level) in LPS induced mice endotoxic shock model[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Unilateral ureteral obstruction (UUO) induced neonatal rats[2]
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Dosage:5 mg/kg
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Administration:i.p., daily
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Result:Attenuated kidney injury (Increased kidney weight and restored renal function).
Inhibited UUO-induced upregulated kidney injury molecule-1 expression, apoptosis, and renal fibrosis.
Chemical Information
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CAS. Nr. 478-03-5
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Molecular Weight 365.39
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Formel C21H19NO5
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SMILES
[OH-].O(C=1C=CC2=C3C=CC=4C=C5OCOC5=CC4C3=[N+](C=C2C1OC)C)C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (8)
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Journal Impact Factor
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Most Recent
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Cell Commun Signal
Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension. [Abstract]2021 Oct 11;19(1):103. PMID: 34635097 -
Cancer Cell Int
High FAAP24 expression reveals poor prognosis and an immunosuppressive microenvironment shaping in AML. [Abstract]2023 Jun 17;23(1):117. PMID: 37328842 -
Front Pharmacol
Propofol Inhibits Ischemia/Reperfusion-Induced Cardiotoxicity Through the Protein Kinase C/Nuclear Factor Erythroid 2-Related Factor Pathway. [Abstract]2021 May 13:12:655726. PMID: 34054535 -
Front Physiol
Roles of Endothelial Motilin Receptor and Its Signal Transduction Pathway in Motilin-Induced Left Gastric Artery Relaxation in Dogs. [Abstract]2021 Oct 28;12:770430. PMID: 34777026 -
FASEB J
EphrinB2/ephB2-mediated myenteric synaptic plasticity: mechanisms underlying the persistent muscle hypercontractility and pain in postinfectious IBS. [Abstract]2019 Dec;33(12):13644-13659. PMID: 31601124 -
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Biochem Biophys Res Commun
2024 Oct 29:739:150914. PMID: 39536412 -
Planta Med
Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus. [Abstract]2024 Jun;90(7-08):523-533. PMID: 38843792
Reinheit & Dokumentation
Verweise
[1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9. [Content Brief]
[2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91. [Content Brief]
[3]. Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6. [Content Brief]
[4]. Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376. [Content Brief]
[5]. Li W, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2012 Dec;35(6):1814-24. [Content Brief]
[6]. He N, et al. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med. 2018 Sep 26;18(1):261. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Chelerythrine hydroxide Related Classifications
HY-N2359A Related Classifications
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