1. Signaling Pathways
  2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2 Family Inhibitors

Bcl-2 Family Inhibitors

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

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Please try each isoform separately.

Bcl-2 Family Inducers, Inhibitors, Antagonists, Activators & Modulators
Product Name Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim Purity
Venetoclax
Bcl-2, Ki: 0.01 nM
Bcl-xL, Ki: 48 nM
Bcl-W, Ki: 245 nM
            99.78%
Navitoclax
Bcl-2, Ki: 1 nM
Bcl-xL, Ki: 1 nM
Bcl-W, Ki: 1 nM
            99.97%
S63845      
MCL1, Kd: 0.19 nM
          99.94%
ABT-737
Bcl-2, EC50: 30.3 nM
Bcl-xL, EC50: 78.7 nM
Bcl-W, EC50: 197.8 nM
Mcl-1, EC50: >10 μM
Bfl-1, EC50: >10 μM
Bcl-B, EC50: 1820 nM
      99.59%
A-1331852
Bcl-2, Ki: 6 nM
Bcl-xL, Ki: 0.01 nM
Bcl-W, Ki: 4 nM
Mcl-1, Ki: 142 nM
          99.65%
n-Butyl-β-D-fructofuranoside
Bcl-2
         
Bax
   
AZD-5991      
Mcl-1, IC50: 0.7 nM
Mcl-1, Kd: 0.17 nM
          99.50%
BT2      
Mcl-1, Ki: 59 μM
          99.56%
A-1155463
Bcl-2, Ki: 80 nM
Bcl-xL, Ki: 0.01 nM
              99.51%
MIK665      
Mcl-1, IC50: 1.81 nM
          99.72%
AZD4320
BCL2, IC50: 17 nM (KPUM-UH1 cells)
BCLxL, IC50: 17 nM (KPUM-UH1 cells)
              99.68%
Obatoclax Mesylate
Bcl-2, Ki: 220 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
      99.74%
Tapotoclax      
Mcl-1, Ki: 0.13 nM
          99.80%
Dehydrocorydaline
Bcl-2
         
Bax
    99.77%
WEHI-539 hydrochloride  
Bcl-xL, IC50: 1.1 nM
              98.31%
BAI1            
Bax
    99.73%
A-1210477
Bcl-2, Ki: 132 nM
 
Bcl-W, Ki: 2280 nM
Mcl-1, Ki: 0.45 nM
Bfl-1, Ki: 660 nM
        98.89%
Bax inhibitor peptide V5            
Bax
    98.12%
Amantadine hydrochloride
Bcl-2
         
Bax
    ≥98.0%
Gambogic Acid
Bcl-2, IC50: 1.21 μM
Bcl-xL, IC50: 1.47 μM
Bcl-W, IC50: 2.02 μM
Mcl-1, IC50: 0.79 μM
Bfl-1, IC50: 1.06 μM
Bcl-B, IC50: 0.66 μM
      98.85%
TCPOBOP
Bcl-2
                98.07%
BTSA1            
Bax, IC50: 250 nM
Bax, EC50: 144 nM
    99.74%
(R)-(-)-Gossypol acetic acid
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
          98.02%
Gossypol
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
              99.56%
XZ739  
Bcl-xL, DC50: 2.5 nM
              99.06%
S55746
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
              99.66%
PROTAC Mcl1 degrader-1
Bcl-2, IC50: 0.54 μM
   
Mcl-1, IC50: 0.78 μM
          98.13%
Gossypol (acetic acid)
Bcl-2, Ki: 0.2-0.3 mM
Bcl-xL, Ki: 0.5-0.6 μM
              99.17%
Dihydrocapsaicin
Bcl-2
Bcl-xL
       
Bax
    98.82%
MSN-125            
Bax
Bak
  98.64%
TW-37
Bcl-2, Ki: 290 nM
Bcl-xL, Ki: 1110 nM
 
Mcl-1, Ki: 260 nM
          99.27%
Paris saponin VII
Bcl-2
                99.13%
(E)-Ferulic acid            
Bax
    99.88%
Sabutoclax
BCL2, IC50: 0.32 μM
Bcl-xL, IC50: 0.31 μM
 
Mcl-1, IC50: 0.2 μM
Bfl-1, IC50: 0.62 μM
       
Jaceosidin            
Bax
    98.00%
Navitoclax-piperazine  
Bcl-xL
              99.21%
PROTAC Bcl2 degrader-1
Bcl-2, DC50: 3 μM
Bcl-2, IC50: 4.94 μM
   
Mcl-1, IC50: 11.81 μM
          98.78%
VU0661013      
Mcl-1
          98.52%
Bz 423            
Bax
Bak
  99.83%
HA14-1
Bcl-2, IC50: 9 μM
                ≥98.0%
Maritoclax      
Mcl-1, IC50: 10.1 μM
          99.97%
BAM7            
Bax, IC50: 3.3 μM
    99.18%
S55746 hydrochloride
Bcl-2, Ki: 1.3 nM
Bcl-2, Kd: 3.9 nM
Bcl-xL, Ki: 520 nM
Bcl-xL, Kd: 186 nM
              98.69%
MIM1      
Mcl-1
          ≥98.0%
MSN-50            
Bax
Bak
  98.40%
TC11      
MCL1
          98.04%
Amantadine
Bcl-2
         
Bax
    ≥98.0%
A-385358
Bcl-2, Ki: 67 nM
Bcl-xL, Ki: 0.8 nM
              98.63%
(S)-Gossypol (acetic acid)
Bcl-2
Bcl-xL
              99.01%
Pyridoclax      
Mcl-1
          99.74%
CLZ-8      
Mcl-1, Ki: 0.3 μM
          ≥98.0%
MCL-1/BCL-2-IN-1
Bcl-2, IC50: 3.18 μM
   
Mcl-1, IC50: 4.45 μM
          98.04%
BH3I-1
Bcl-2
Bcl-xL
         
Bak
Bim
≥98.0%
IMB-XH1      
Mcl-1
          ≥98.0%
Destruxin B
Bcl-2
                99.35%
Mcl1-IN-1      
Mcl-1, IC50: 2.4 μM
          98.40%
Murizatoclax      
MCL1, Ki: 15 pM
         
Mcl-1 inhibitor 6
Bcl-2, Kd: >10 μM
Bcl2A1, Kd: >10 μM
Bcl-2, Ki: 10 μM
Bcl-xL, Kd: >10 μM
Bcl-W, Kd: >10 μM
Mcl-1, Kd: 0.23 nM
Mcl-1, Ki: 0.02 μM
Bfl-1, Ki: 1.57 μM
        98.40%
(+)-Apogossypol
Bcl-2, EC50: 2.8 μM
Bcl-xL, EC50: 3.69 μM
 
Mcl-1, EC50: 2.6 μM
         
ML311      
Mcl-1
       
Bim
98.26%
Thevetiaflavone
Bcl-2
         
Bax
   
(R)-(-)-Gossypol
Bcl-2, Ki: 260 nM
Bcl-xL, Ki: 480 nM
 
Mcl-1, Ki: 170 nM
         
WEHI-539  
Bcl-xL, IC50: 1.1 nM
             
Obatoclax
BCL2, Ki: 200 nM
Bcl-xL, Ki: 1-7 μM
Bcl-W, Ki: 1-7 μM
Mcl-1, Ki: 1-7 μM
 
Bcl-B, Ki: 1-7 μM
     
PROTAC Bcl-xL degrader-1  
Bcl-xL
             
L6H21
Bcl-2
         
Bax
   
Mcl1-IN-9      
Mcl-1, Ki: 0.03 nM
         
PROTAC Bcl-xL degrader-3  
Bcl-xL
             
Lisaftoclax
Bcl-2, IC50: 2 nM
Bcl-xL, IC50: 5.9 nM
              98.73%
AZD-5991 Racemate      
Mcl-1, IC50: 3 nM
         
AZD-5991 (S-enantiomer)      
Mcl-1, IC50: 6.3 μM
Mcl-1, Kd: 0.98 μM
         
Apogossypolone
Bcl-2, Ki: 35 nM
Bcl-xL, Ki: 660 nM
 
Mcl-1, Ki: 25 nM
         
PROTAC Bcl-xL degrader-2  
Bcl-xL, IC50: 0.6 nM
             
GL0388            
Bax
   
BM-1197
Bcl-2, IC50: 3.5 nM
Bcl-xL, IC50: 5.2 nM
             
Mcl-1 inhibitor 3      
Mcl-1, IC50: 19 nM
Mcl-1, Ki: 0.061 nM
         
Amantadine sulfate
Bcl-2
         
Bax
   
BM 957
Bcl-2, IC50: 5.4 nM
Bcl-2, Ki: 1.2 nM
Bcl-xL, IC50: 6.0 nM
Bcl-xL, Ki: <1 nM
             
Bcl-2-IN-10            
Bax
   
Antitumor agent-77
Bcl-2
         
Bax
   
Bcl-2-IN-4
Bcl-2, IC50: 1.5 nM
Bcl-xL, IC50: 411 nM
             
MNK8
Bcl-2
               
Bcl-2/Mcl-1-IN-2
Bcl-2, Ki: 4.70 μM
   
Mcl-1, Ki: 0.88 μM
         
BRD4 Inhibitor-15
Bcl-2
         
Bax
   
Antitumor agent-78
Bcl-2
         
Bax
   
JNJ-4355      
Mcl-1, Ki: 18 pM
         
BM-1074
Bcl-2, IC50: 1.8 nM
Bcl-xL, IC50: 6.9 nM
             
Apoptotic agent-2
Bcl-2
         
Bax
   
Bcl-2-IN-9
Bcl-2, IC50: 2.9 μM ([1])
               
BBR-BODIPY            
Bax
   
Bcl-2/Mcl-1-IN-1
Bcl-2, Ki: 4.53 μM
   
Mcl-1, Ki: 1.19 μM
         
Anticancer agent 64
Bcl-2
         
Bax
   
Bcl-2-IN-5
Bcl-2, IC50: 0.12 nM
               
CYD-4-61            
Bax
   
Bcl-2-IN-6
Bcl-2
         
Bax
   
Aviculin
Bcl-2
         
Bax
   
Bcl-2/Mcl-1-IN-3
Bcl-2, Ki: 0.23 μM
Bcl-xL, Ki: 15 μM
 
Mcl-1, Ki: 0.14 μM
         
Bim-IN-1                
Bim
Bcl-2-IN-7
Bcl-2
         
Bax
   
BDA-366
Bcl-2, Ki: 3.3 nM
               
CDK1/2/4-IN-1
Bcl-2
         
Bax
   
Bcl-2-IN-2
Bcl-2, IC50: 0.034 nM
Bcl-xL, IC50: 43 nM
             
Apoptotic agent-3
Bcl-2
         
Bax
   
Anticancer agent 43            
Bax
   
PUMA BH3              
Bak, Kd: 26 nM
 
Isolinderalactone
Bcl-2
               
Bax activator-1            
Bax
   
Bcl-2-IN-8
Bcl-2
         
Bax
   
Anticancer agent 65
Bcl-2
         
Bax
   
Anticancer agent 63
Bcl-2
               
PUMA BH3 TFA              
Bak, Kd: 26 nM
 
Bak BH3  
Bcl-xL