34316-15-9
Chemical Structure
Chelerythrine
- CAS No.: 34316-15-9
- Formula:C21H18NO4
- Molecular Weight:348.37
IUPAC Name: 1,2-dimethoxy-12-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridin-12-ium
InChIKey: LLEJIEBFSOEYIV-UHFFFAOYSA-N
SMILES: C[N+]1=CC2=C(OC)C(OC)=CC=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5
Biological Activity: Chelerythrine is an alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM. Chelerythrine triggers Apoptosis and Autophagy. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine shows antibacterial activities against Gram-positive bacteria, Staphylococcus aureus (SA), MRSA[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Chelerythrine | Chelerythrine is an alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM. Chelerythrine triggers Apoptosis and Autophagy. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine shows antibacterial activities against Gram-positive bacteria, Staphylococcus aureus (SA), MRSA. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Chelerythrine-d6 chloride | Chelerythrine-d6 is the deuterium labeled Chelerythrine (HY-N2359). Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with an IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine triggers apoptosis and autophagy. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9. [Content Brief]
- [2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91. [Content Brief]
- [3]. Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6. [Content Brief]
- [4]. Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376. [Content Brief]
- [5]. Li W, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2012 Dec;35(6):1814-24. [Content Brief]
- [6]. He N, et al. Antibacterial mechanism of chelerythrine isolated from root of Toddalia asiatica (Linn) Lam. BMC Complement Altern Med. 2018 Sep 26;18(1):261. [Content Brief]
