HMGB1-IN-1
Based on 1 Customer Validation
HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC50 value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury.
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- Pureté : 98.40%
- Formule: C57H75N3O15
- Masse moléculaire:1042.22
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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IL-1β |
NLRP3 |
In Vitro
HMGB1-IN-1 (compound 6) (0-30 μM, 0-48 h) not only decreases IL-1β and TNF-α levels in RAW264.7 cells and HK-2 cells, but also down-regulates the levels of NLRP3, P-NF-κB p65 and HMGB1 in activated HK-2 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (8-10 weeks old, 20±5 g)[1]
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Dosage:15, 30 mg/kg
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Administration:Intraperitoneal injection, once a day for 7 consecutive days
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Result:Decreased the expression levels of IL-1β to 70.1% at 15 mg/kg, and further decreased to 31.4% at 30 mg/kg. Downregulated TNF-α to 37.3%.
Chemical Information
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Appearance Solid
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Masse moléculaire 1042.22
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Formule C57H75N3O15
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Color White to off-white
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SMILES
O=C(C=C1[C@@]2([C@@](CC[C@@]31C)(CC[C@@](C)(C2)C(OCC4=CN([C@@H]5O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]5OC(C)=O)N=N4)=O)C)[H])[C@@]6([C@@](CC[C@@H](C7(C)C)OC(/C=C/C8=CC=C(OC)C=C8)=O)(C7CC[C@@]36C)C)[H]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (119.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9595 mL | 4.7975 mL | 9.5949 mL | 23.9873 mL |
| 5 mM | 0.1919 mL | 0.9595 mL | 1.9190 mL | 4.7975 mL | |
| 10 mM | 0.0959 mL | 0.4797 mL | 0.9595 mL | 2.3987 mL | |
| 15 mM | 0.0640 mL | 0.3198 mL | 0.6397 mL | 1.5992 mL | |
| 20 mM | 0.0480 mL | 0.2399 mL | 0.4797 mL | 1.1994 mL | |
| 25 mM | 0.0384 mL | 0.1919 mL | 0.3838 mL | 0.9595 mL | |
| 30 mM | 0.0320 mL | 0.1599 mL | 0.3198 mL | 0.7996 mL | |
| 40 mM | 0.0240 mL | 0.1199 mL | 0.2399 mL | 0.5997 mL | |
| 50 mM | 0.0192 mL | 0.0959 mL | 0.1919 mL | 0.4797 mL | |
| 60 mM | 0.0160 mL | 0.0800 mL | 0.1599 mL | 0.3998 mL | |
| 80 mM | 0.0120 mL | 0.0600 mL | 0.1199 mL | 0.2998 mL | |
| 100 mM | 0.0096 mL | 0.0480 mL | 0.0959 mL | 0.2399 mL |
HMGB1-IN-1 Related Classifications
HY-155751 Related Classifications
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