1. Apoptosis
  2. Apoptosis
  3. Silybin

Silybin 

Cat. No.: HY-N0779A
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Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.

For research use only. We do not sell to patients.

Silybin Chemical Structure

Silybin Chemical Structure

CAS No. : 802918-57-6

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Description

Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].

In Vitro

Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner[1].
Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%[1].
Silybin (68 μM; for 72 hours) induces AKT activity inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cell growth
Concentration: 0-200 mM
Incubation Time: For 72 hours
Result: Had growth inhibition in a time- and dose-dependent manner with an IC50 of 68 μM.

Apoptosis Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced apoptosis in a higher number of cells (60%) when compared to untreated cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Increased the cells in G1-phase of ~22% and decreased of 47% the cells in S-phase.

Western Blot Analysis[1]

Cell Line: HepG2 cell growth
Concentration: 68 μM
Incubation Time: For 72 hours
Result: Induced AKT activity inhibition.
In Vivo

Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (6-8 weeks old) with nonalcoholic fatty liver disease (NAFLD)[2]
Dosage: 50, 100 mg/kg
Administration: Given intragastrically; daily; for the last 4 weeks
Result: Significantly lowered both serum and hepatic lipid accumulation.
Molecular Weight

482.44

Formula

C₂₅H₂₂O₁₀

CAS No.

802918-57-6

SMILES

O=C1[[email protected]](O)[[email protected]@H](C2=CC=C(OC(CO)C(C3=CC=C(O)C(OC)=C3)O4)C4=C2)OC5=CC(O)=CC(O)=C15

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SilybinApoptosismilkthistlehepatoprotectiveantioxidantanti-inflammatoryanti-cancerHepG2G1-phaseS-phaseAKTInhibitorinhibitorinhibit

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Silybin
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