Cycloartane triterpenoids from Kleinhovia hospita

  • J Nat Prod. 2009 Jun;72(6):1102-5. doi: 10.1021/np900029z.
Li-She Gan  1 ,  Gang Ren ,  Jian-Xia Mo ,  Xiang-Yi Zhang ,  Wei Yao ,  Chang-Xin Zhou
Affiliations
  • 1. Institute of Modern Chinese Medicine (IMCM), College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People's Republic of China.
PMID: 19489592 DOI: 10.1021/np900029z
Abstract

Four new cycloartane triterpenoids, together with the known gardenolic acid B, were isolated from Kleinhovia hospita. The triterpenoids (1-3) contain a unique 21,23-diacetal side-chain, while compound 4 contains two alpha,beta-unsaturated ketone moieties. Their structures and relative configurations were determined by spectroscopic methods, including 2D NMR and IR. These compounds showed promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.