Lutein (Synonyms: Xanthophyll)

Cat. No.: HY-N6947: FAQs
Data Sheet SDS COA Handling Instructions

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Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

For research use only. We do not sell to patients.

Lutein Chemical Structure

CAS No. : 127-40-2

Size	Price	Stock
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 63	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO	USD 63	Ask For Quote & Lead Time
Solid
5 mg	USD 50	Ask For Quote & Lead Time
10 mg	USD 80	Ask For Quote & Lead Time
20 mg	USD 140	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

2 Publications Citing Use of MCE Lutein

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Biological Activity
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Description

Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health^[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS)^[2]^[3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active^[4].

In Vitro

Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats^[3].
Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats, severe traumatic brain injury (STBI) model^[3]
Dosage:	40, 80 and 160 mg/kg
Administration:	In diet for 5 weeks
Result:	Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.

Animal Model:	Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression^[4]
Dosage:	0.1, 1 and 10 mg/kg
Administration:	Oral administration, once or daily for 7 and 21 days
Result:	Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.

Clinical Trial

Molecular Weight

568.87

Formula

C₄₀H₅₆O₂

CAS No.

127-40-2

Appearance

Solid

Color

Orange to red

SMILES

CC(/C=C/[C@@H](C(C)=C[C@H](O)C1)C1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2)C)=C2C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (87.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7579 mL	8.7894 mL	17.5787 mL
5 mM	0.3516 mL	1.7579 mL	3.5157 mL
10 mM	0.1758 mL	0.8789 mL	1.7579 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 89.49%

Select Batch:

Data Sheet (244 KB) SDS (0 KB)

COA (240 KB) HNMR (127 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7579 mL	8.7894 mL	17.5787 mL	43.9468 mL
	5 mM	0.3516 mL	1.7579 mL	3.5157 mL	8.7894 mL
	10 mM	0.1758 mL	0.8789 mL	1.7579 mL	4.3947 mL
	15 mM	0.1172 mL	0.5860 mL	1.1719 mL	2.9298 mL
	20 mM	0.0879 mL	0.4395 mL	0.8789 mL	2.1973 mL
	25 mM	0.0703 mL	0.3516 mL	0.7031 mL	1.7579 mL
	30 mM	0.0586 mL	0.2930 mL	0.5860 mL	1.4649 mL
	40 mM	0.0439 mL	0.2197 mL	0.4395 mL	1.0987 mL
	50 mM	0.0352 mL	0.1758 mL	0.3516 mL	0.8789 mL
	60 mM	0.0293 mL	0.1465 mL	0.2930 mL	0.7324 mL
	80 mM	0.0220 mL	0.1099 mL	0.2197 mL	0.5493 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lutein127-40-2XanthophyllInhibitorinhibitorinhibit

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