2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)
  4. Lutein

Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS). Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active.

For research use only. We do not sell to patients.

CAS No. : 127-40-2

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Based on 4 publication(s) in Google Scholar

Lutein Related Antibodies

Top Publications Citing Use of Products

    Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186.

    Lutein (3 μM) progressively lessened the amplitude of Ih in pituitary GH3 cells evoked in response to such 2-sec long step hyperpolarization from -40 to -120 mV.

    Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186.

    Lutein (0.1-100 μM) concentration-dependently inhibited the amplitude of hyperpolarization-activated cation current (Ih) in pituitary GH3 cells.

    Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186.

    Lutein (1-3 μM) increased the τact value of Ih in pituitary GH3 cells evoked by long-lasting membrane hyperpolarization.

    Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186.

    Modifications of Lutein (3 μM) on the quasi-steady-state activation curve of hyperpolarization-activated cation current (Ih) seen in GH3 cells.

    Lutein purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Jun 28;23(13):7186.

    The application of Lutein (1–3 μM) resulted in a conceivable depression of the sag potential evoked in response to a hyperpolarizing current stimulus in GH3 cells.

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    Description

    Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health[1]. Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS)[2][3]. Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active[4].

    In Vitro

    Lutein (100 or 200 μM) protects against A2-PE (a bis-retinoid compound that is the immediate precursor of the lipofuscin fluorophore A2E) photooxidation and reduces A2E photooxidation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Lutein Related Antibodies
    In Vivo

    Lutein (40-160 mg/kg; in diet for 5 weeks) protects against severe traumatic brain injury through anti-inflammation and anti-oxidative effects via ICAM-1/Nrf-2 in rats[3].
    Lutein (0.1-10 mg/kg; p.o.; once or daily for 7 and 21 days) prevents Corticosterone.html" class="link-product" target="_blank">Corticosterone (HY-B1618)-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Sprague-Dawley rats, severe traumatic brain injury (STBI) model[3]
    Dosage: 40, 80 and 160 mg/kg
    Administration: In diet for 5 weeks
    Result: Suppressed, interleukin (IL)-1β, IL-6 and monocyte chemoattractant protein-1 expression, reduced serum ROS levels, and reduced superoxide dismutase and glutathione peroxidase activities. Effectively downregulated the expression of NF-κB p65 and cyclooxygenase-2, intercellular adhesion molecule (ICAM)-1 protein, and upregulated nuclear factor erythroid 2 like 2 (Nrf-2) and endothelin-1 protein levels.
    Animal Model: Male Swiss mice, chronic Corticosterone (HY-B1618) model of depression[4]
    Dosage: 0.1, 1 and 10 mg/kg
    Administration: Oral administration, once or daily for 7 and 21 days
    Result: Decreased immobility time at the dose 10 mg/kg. Counteracted the behavioral changes displayed by Corticosterone (HY-B1618) showing antidepressant-like effect. Presented antioxidant effect in the hippocampus, prefrontal cortex and plasma of mice, and exhibited a capability to protect hippocampal and prefrontal cortex slices against glutamatergic toxicity.
    Clinical Trial
    Molecular Weight

    568.87

    Formula

    C40H56O2
    CAS No.
    Appearance

    Solid

    Color

    Orange to red

    SMILES

    CC(/C=C/[C@@H](C(C)=C[C@H](O)C1)C1(C)C)=C\C=C\C(C)=C\C=C\C=C(C)\C=C\C=C(C)\C=C\C(C(C)(C[C@H](O)C2)C)=C2C
    Structure Classification
    Initial Source

    egg's yolk
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (43.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7579 mL 8.7894 mL 17.5787 mL
    5 mM 0.3516 mL 1.7579 mL 3.5157 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Purity & Documentation

    Purity: 90.0%

    SDS (393 KB)

    COA (240 KB) HNMR (325 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.7579 mL 8.7894 mL 17.5787 mL 43.9468 mL
    5 mM 0.3516 mL 1.7579 mL 3.5157 mL 8.7894 mL
    10 mM 0.1758 mL 0.8789 mL 1.7579 mL 4.3947 mL
    15 mM 0.1172 mL 0.5860 mL 1.1719 mL 2.9298 mL
    20 mM 0.0879 mL 0.4395 mL 0.8789 mL 2.1973 mL
    25 mM 0.0703 mL 0.3516 mL 0.7031 mL 1.7579 mL
    30 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4649 mL
    40 mM 0.0439 mL 0.2197 mL 0.4395 mL 1.0987 mL
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    Lutein Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Lutein127-40-2XanthophyllEndogenous MetaboliteApoptosisReactive Oxygen Species (ROS)A2-PEA2Emacular degenerationICAM-1Nrf-2CorticosteroneInhibitorinhibitorinhibit

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