PGN-9856

Cat. No.: HY-115462 Purity: 98.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PGN-9856 is a selective and high affinity (pK_i ≥ 8.3) ligand at EP2 receptor. PGN-9856 is a potetn and non-prostanoid EP2 receptor agonist (pEC₅₀ ≥ 8.5). PGN-9856 shows anti-inflammatory and anti-glaucoma activities.

For research use only. We do not sell to patients.

PGN-9856 Chemical Structure

CAS No. : 863704-91-0

Size	Price	Stock	Quantity
5 mg	USD 265	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Purity & Documentation
References
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Description

IC₅₀ & Target

EP2

≥ 8.5 (pEC₅₀)

EP2

≥ 8.3 (pKi)

Molecular Weight

383.34

Formula

C₂₁H₁₅F₂NO₄

CAS No.

863704-91-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=CC(NC(C2=CC(C3=CC=CC(F)=C3)=CC=C2F)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (326.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6087 mL	13.0433 mL	26.0865 mL
5 mM	0.5217 mL	2.6087 mL	5.2173 mL
10 mM	0.2609 mL	1.3043 mL	2.6087 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.90%

Select Batch:

Data Sheet (268 KB) SDS (251 KB)

COA (244 KB) HNMR (266 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Coleman RA, et al. The affinity, intrinsic activity and selectivity of a structurally novel EP2 receptor agonist at human prostanoid receptors. Br J Pharmacol. 2019 Mar;176(5):687-698. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6087 mL	13.0433 mL	26.0865 mL	65.2163 mL
	5 mM	0.5217 mL	2.6087 mL	5.2173 mL	13.0433 mL
	10 mM	0.2609 mL	1.3043 mL	2.6087 mL	6.5216 mL
	15 mM	0.1739 mL	0.8696 mL	1.7391 mL	4.3478 mL
	20 mM	0.1304 mL	0.6522 mL	1.3043 mL	3.2608 mL
	25 mM	0.1043 mL	0.5217 mL	1.0435 mL	2.6087 mL
	30 mM	0.0870 mL	0.4348 mL	0.8696 mL	2.1739 mL
	40 mM	0.0652 mL	0.3261 mL	0.6522 mL	1.6304 mL
	50 mM	0.0522 mL	0.2609 mL	0.5217 mL	1.3043 mL
	60 mM	0.0435 mL	0.2174 mL	0.4348 mL	1.0869 mL
	80 mM	0.0326 mL	0.1630 mL	0.3261 mL	0.8152 mL
	100 mM	0.0261 mL	0.1304 mL	0.2609 mL	0.6522 mL

PGN-9856 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PGN-9856863704-91-0PGN9856PGN 9856Prostaglandin ReceptorProstaglandinEP2 receptorinflammationTNFαIL-2monocyteslymphocytemyometriumglaucomaInhibitorinhibitorinhibit

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