1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC chemokine subfamily
  5. MPIF-1/CCL23 Protein, Human (75a.a)

MPIF-1/CCL23 Protein, Human (75a.a)

Cat. No.: HY-P7765
Handling Instructions

MPIF-1/CCL23 Protein, Human (75a.a) is a member of the small CC chemokine family implicated in inflammation and host defense responses.

For research use only. We do not sell to patients.

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Recombinant Proteins-MedChemExpress
Size Price Stock Quantity
10 μg $130 In-stock
Estimated Time of Arrival: December 31
50 μg $390 In-stock
Estimated Time of Arrival: December 31
100 μg   Get quote  
250 μg   Get quote  

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MPIF-1/CCL23 Protein, Human (75a.a) Related Classifications

  • Technical Parameters

  • Properties

  • Documentation

Species

Human

Source

E. coli

Accession

P55773 (R46-N120)

Gene ID

6368

Synonyms
rHuCCL23; C-C Motif Chemokine 23; CKB-8; Macrophage Inflammatory Protein 3; MIP-3; Myeloid Progenitor Inhibitory Factor 1; MPIF-1; CCL23; MIP3; MPIF1; SCYA23
AA Sequence

RFHATSADCCISYTPRSIPCSLLESYFETNSECSKPGVIFLTKKGRRFCANPSDKQVQVCVRMLKLDTRIKTRKN

Molecular Weight

Approximately 11 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity
Data is not available.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against 20 mM PB, 250 mM NaCl, pH 7.2.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

CC chemokine ligand 23 (CCL23) is a new member of the small CC chemokine family that has recently been associated with the pathophysiology of various inflammatory conditions. CCL23 is a potent suppressor of hematopoiesis due to its capacity to inhibit colony formation of myeloid progenitors. The secreted CCL23 also functionally contributes to modulation of the immune response via promoting leukocyte trafficking as well as directing the migration of monocytes, macrophages and activated T lymphocytes to local sites of injury. Circulating CCL23 interacts with CC chemokine receptor 1 (CCR1), subsequent up-regulating several adhesion molecules that promote the migration of circulating immune cells to the inflamed microenvironment. Activation of the CCL23-CCR1 axis also stimulates the production of other pro-inflammatory cytokines, including macrophage inflammatory protein (MIP)-1α, interleukin (IL)-1β and tumor necrosis factor (TNF)-α, and boosts angiogenesis via promotion of endothelial cell migration through up-regulation of several matrix metalloproteinases in the endothelium[1].

Documentation
References
  • Reconstitution Calculator

  • Dilution Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
MPIF-1/CCL23 Protein, Human (75a.a)
Cat. No.:
HY-P7765
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