TIMP-1
TIMP-1 (tissue inhibitor of metalloproteinases 1) is a glycosylated secreted protein that inhibits most matrix metalloproteinases, with particularly high affinity for MMP-9, and forms complexes with proMMP-9 and membrane-type MMP-14. Its gene is X-linked and strongly inducible by cytokines and growth factors. Beyond protease inhibition, TIMP-1 acts as a signaling molecule: through CD63 and integrin-associated receptors it promotes cell survival, proliferation and erythroid differentiation, giving it cytokine-like functions independent of MMP binding. Elevated circulating TIMP-1 correlates with poor prognosis in breast, colorectal and other cancers and with fibrotic disease. Recombinant TIMP-1 is a standard reagent for MMP activity assays and tumor microenvironment studies.
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TIMP-1 Recombinant Proteins (6)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
