Acazicolcept
Based on 1 publication(s) in Google Scholar
Acazicolcept (ALPN-101), an Fc fusion protein, is a dual inducible T cell costimulator (ICOS)/CD28 antagonist. Acazicolcept has anti-inflammatory activities.
For research use only. We do not sell to patients.
- Purity: 99.27%
- CAS No.: 2797026-97-0
- Molecular Weight:80.82 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Acazicolcept
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-week-old female BALB/c mice induced by hypochlorous acid (HOCL)[1]
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Dosage:267 μg/mouse and 400 μg/mouse
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Administration:i.p.; twice a week; for 6 weeks
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Result:Induced a significant decrease in dermal thickness, collagen content, myofibroblast number, and inflammatory infiltrates characterized by B cells, T cells, neutrophils, and macrophages.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[ICOSLG (inducible T-cell co-stimulator ligand, B7H2, B7-H2, ICOS-L, B7-related protein 1, B7RP1, B7RP-1, B7 homolog 2, B7 homologue 2, GL50, KIAA0653, CD275)N-terminal fragment (1-122)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
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Immobilized Acazicolcept can bind Human ICOS Protein (His Tag). The EC50 for this effect is 0.43 ng/mL.
Chemical Information
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CAS No. 2797026-97-0
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Appearance Liquid
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Molecular Weight 80.82 kDa
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Color Colorless to light yellow
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SMILES
[Acazicolcept]
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Synonyms
ALPN-101
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)