1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. P-glycoprotein
    AChE
  3. Sinapine thiocyanate

Sinapine thiocyanate 

Cat. No.: HY-N0450 Purity: 98.32%
Handling Instructions

Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

For research use only. We do not sell to patients.

Sinapine thiocyanate Chemical Structure

Sinapine thiocyanate Chemical Structure

CAS No. : 7431-77-8

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10 mM * 1 mL in DMSO USD 79 In-stock
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10 mg USD 72 In-stock
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25 mg USD 108 In-stock
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50 mg USD 156 In-stock
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100 mg USD 276 In-stock
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200 mg USD 480 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4].

IC50 & Target

AChE[4], P-gp[1]

In Vitro

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes[1].
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity[3].
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease[3].
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

368.45

Formula

C₁₇H₂₄N₂O₅S

CAS No.

7431-77-8

SMILES

COC1=C(O)C(OC)=CC(C=CC(OCC[N+](C)(C)C)=O)=C1.N#C[S-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (339.26 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7141 mL 13.5704 mL 27.1407 mL
5 mM 0.5428 mL 2.7141 mL 5.4281 mL
10 mM 0.2714 mL 1.3570 mL 2.7141 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 12.5 mg/mL (33.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 12.5 mg/mL (33.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 12.5 mg/mL (33.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.32%

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Keywords:

SinapineP-glycoproteinAChEP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Acetylcholinesterasecruciferousanti-inflammatoryanti-oxidantanti-tumoranti-angiogenicradio-protectiveacetylcholinesteraseAlzheimer’sdiseaseataxiamyastheniagravisParkinson’sInhibitorinhibitorinhibit

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Product Name:
Sinapine thiocyanate
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HY-N0450
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