1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. AChE
    P-glycoprotein
  3. Sinapine hydroxide

Sinapine hydroxide 

Cat. No.: HY-N5077B
Handling Instructions

Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.

For research use only. We do not sell to patients.

Sinapine hydroxide Chemical Structure

Sinapine hydroxide Chemical Structure

CAS No. : 122-30-5

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Description

Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4].

IC50 & Target

AChE[4], P-gp[1]

In Vitro

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes[1].
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity[3].
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease[3].
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2[3].

In Vivo

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota[2].

Molecular Weight

327.37

Formula

C₁₆H₂₅NO₆

CAS No.

122-30-5

SMILES

O=C(OCC[N+](C)(C)C)/C=C/C(C=C1OC)=CC(OC)=C1O.[OH-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SinapineAChEP-glycoproteinAcetylcholinesteraseP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243cruciferousanti-inflammatoryanti-oxidantanti-tumoranti-angiogenicradio-protectiveacetylcholinesteraseAlzheimer’sdiseaseataxiamyastheniagravisParkinson’sInhibitorinhibitorinhibit

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Sinapine hydroxide
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HY-N5077B
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