Sinapine hydroxide
Based on 2 publication(s) in Google Scholar
Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease.
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- No. CAS: 122-30-5
- Fòrmula: C16H25NO6
- Peso molecular:327.37
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Sinapine hydroxide
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Actividad biológica
Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes[1].
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity[3].
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease[3].
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 122-30-5
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Peso molecular 327.37
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Fòrmula C16H25NO6
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SMILES
O=C(OCC[N+](C)(C)C)/C=C/C(C=C1OC)=CC(OC)=C1O.[OH-]
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cancer Biol Ther
Sinapine thiocyanate exhibited anti-colorectal cancer effects by inhibiting KRT6A/S100A2 axis. [Abstract]2023 Dec 31;24(1):2249170. PMID: 37647260 -
J Cancer
Sinapine Thiocyanate Inhibits the Proliferation and Mobility of Pancreatic Cancer Cells by Up-Regulating GADD45A. [Abstract]2022 Jan 24;13(4):1229-1240. PMID: 35281859
Pureza y Documentación
Referencias
[1]. Boulghobra D, et, al. Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes. Redox Biol. 2020 Jul;34:101554. [Content Brief]
[2]. Li Y, et, al. Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. Food Funct. 2019 Jun 19;10(6):3637-3649. [Content Brief]
[3]. Guo Y, et, al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. [Content Brief]
[4]. Yates K, et, al. Determination of sinapine in rapeseed pomace extract: Its antioxidant and acetylcholinesterase inhibition properties. Food Chem. 2019 Mar 15;276:768-775. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sinapine hydroxide Related Classifications
HY-N5077B Related Classifications
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