Cat. No.: HY-N1205

Spathulenol

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Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC₅₀ of 85.60 μg/mL in the DPPH system.

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Pureté: 99.20%
CAS No.: 6750-60-3
Formule: C₁₅H₂₄O
Masse moléculaire:220.35

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Spathulenol Chemical Structure

CAS No.: 6750-60-3

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Activité biologique
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 1517737]
BC1 cell line	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human BC1 cells Cytotoxicity against human BC1 cells	[PMID: 1517737]
BC1 cell line	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against human BC1 cells Cytotoxicity against human BC1 cells	[PMID: 7931367]
Col2	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 1517737]
Col2	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 7931367]
HT-1080	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human HT1080 cells Cytotoxicity against human HT1080 cells	[PMID: 1517737]
HT-1080	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against human HT1080 cells Cytotoxicity against human HT1080 cells	[PMID: 7931367]
KB	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 1517737]
KB	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 7931367]
KB-V1	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human vinblastine-resistant KBV1 cells Cytotoxicity against human vinblastine-resistant KBV1 cells	[PMID: 1517737]
KB-V1	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against human KBV1 cells Cytotoxicity against human KBV1 cells	[PMID: 7931367]
LNCaP	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 1517737]
Lu1	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 1517737]
Lu1	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 7931367]
P388	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 1517737]
P388	ED₅₀	>20 μg/mL Compound: spathulenol	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 7931367]
SK-MEL-2	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human SK-MEL-2 cells Cytotoxicity against human SK-MEL-2 cells	[PMID: 1517737]
SK-MEL-2	ED₅₀	6.3 μg/mL Compound: spathulenol	Cytotoxicity against human SK-MEL-2 cells Cytotoxicity against human SK-MEL-2 cells	[PMID: 7931367]
ZR-75-1	ED₅₀	>20 μg/mL Compound: (+)-Spathulenol	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 1517737]

In Vitro

Spathulenol exhibits a high antioxidant activity s in the DPPH and MDA system, exhibits significant DPPH free radical activity, with IC₅₀ values of 85.60 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Spathulenol (oral administration; 300 mg/kg) shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model^[1].
In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature andoxygenation conditions, PG-1 exhibits a high activity with an IC₅₀ value of 26.13 μg/mL, respectively, which iscomparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA,which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6750-60-3
Appearance Liquid (Density: 1.02±0.1 g/cm³)
Masse moléculaire 220.35
Formule C₁₅H₂₄O
Color Colorless to light yellow
SMILES

O[C@@]([C@@]1([H])[C@@](C2(C)C)([H])[C@@]2([H])CC3)(C)CC[C@@]1([H])C3=C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- other families
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (453.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5382 mL

22.6912 mL

45.3823 mL

5 mM

0.9076 mL

4.5382 mL

9.0765 mL

10 mM

0.4538 mL

2.2691 mL

4.5382 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (282 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nascimento KF, et al. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol.J Ethnopharmacol. 2018 Jan 10;210:351-358. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.5382 mL	22.6912 mL	45.3823 mL	113.4559 mL
	5 mM	0.9076 mL	4.5382 mL	9.0765 mL	22.6912 mL
	10 mM	0.4538 mL	2.2691 mL	4.5382 mL	11.3456 mL
	15 mM	0.3025 mL	1.5127 mL	3.0255 mL	7.5637 mL
	20 mM	0.2269 mL	1.1346 mL	2.2691 mL	5.6728 mL
	25 mM	0.1815 mL	0.9076 mL	1.8153 mL	4.5382 mL
	30 mM	0.1513 mL	0.7564 mL	1.5127 mL	3.7819 mL
	40 mM	0.1135 mL	0.5673 mL	1.1346 mL	2.8364 mL
	50 mM	0.0908 mL	0.4538 mL	0.9076 mL	2.2691 mL
	60 mM	0.0756 mL	0.3782 mL	0.7564 mL	1.8909 mL
	80 mM	0.0567 mL	0.2836 mL	0.5673 mL	1.4182 mL
	100 mM	0.0454 mL	0.2269 mL	0.4538 mL	1.1346 mL

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Spathulenol

MCE Bioactive Compound Library

Natural Product Library Plus

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Spathulenol

MCE Bioactive Compound Library

Natural Product Library Plus

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Spathulenol Related Classifications

HY-N1205 Related Classifications