2. Natural Products
  3. Disease Research Fields Plants Terpenoids
  4. Aristolochiaceae Cancer other families Sesquiterpenes
  5. Aristolochia yunnanensis
  6. Spathulenol

Spathulenol 

Cat. No.: HY-N1205 Purity: ≥95.0%
COA Handling Instructions

Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].

For research use only. We do not sell to patients.

Spathulenol Chemical Structure

Spathulenol Chemical Structure

CAS No. : 6750-60-3

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1 mg USD 230 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Spathulenol Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1].

In Vitro

Spathulenol exhibits a high antioxidant activity s in the DPPH and MDA system, exhibits significant DPPH free radical activity, with IC50 values of 85.60 μg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spathulenol Related Antibodies
In Vivo

Spathulenol (oral administration; 300 mg/kg) shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model[1].
In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature and oxygenation conditions, PG-1 exhibits a high activity with an IC50 value of 26.13 μg/mL, respectively, which is comparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA, which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

220.35

Appearance

Liquid

Formula

C15H24O
CAS No.
SMILES

O[C@@]([C@@]1([H])[C@@](C2(C)C)([H])[C@@]2([H])CC3)(C)CC[C@@]1([H])C3=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (453.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5382 mL 22.6912 mL 45.3823 mL
5 mM 0.9076 mL 4.5382 mL 9.0765 mL
10 mM 0.4538 mL 2.2691 mL 4.5382 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥95.0%

COA (262 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Spathulenol6750-60-3OthersPG-1 paw oedema pleurisyntioxidantInhibitorinhibitorinhibit

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