Meloxicam sodium
Based on 14 publication(s) in Google Scholar
Meloxicam sodium is a non-steroidal anti-inflammatory agent that can pass through the blood-brain barrier, inhibits COX activity, with IC50s of 0.49 μM and 36.6 μM for COX-2 and COX-1, respectively.
For research use only. We do not sell to patients.
- CAS No.: 71125-39-8
- Formula: C14H12N3NaO4S2
- Molecular Weight:373.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Meloxicam sodium
More- Adv Funct Mater. 2025 Apr 21.
- Neuron. 2024 Nov 6;112(21):3651-3664.e8. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Emerg Contam. 2026 Feb 23.
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Biochem Pharmacol. 2024 Sep 11:116532. [Abstract]
- Chem Biol Interact. 2021 Apr 1:338:109425. [Abstract]
- Int Immunopharmacol. 2026 Jan 1;168(Pt 2):115861. [Abstract]
- Sci Rep. 2025 Jul 9;15(1):24614. [Abstract]
- Sci Rep. 2025 Jul 9;15(1):24789. [Abstract]
- JOR Spine. 2023 Oct 18;7(1):e1290. [Abstract]
- Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. [Abstract]
- Cell Transplant. 2025 Jan-Dec:34:9636897251376125. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):3313-3329. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
Biological Activity
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COX-2 0.49 μM (IC50) |
COX-1 36.6 μM (IC50) |
MMP-2 |
Meloxicam sodium (0.25 μg/mL) decreases CF41.Mg cell migration and invasion, induces decrease in MMP-2 expression, and increases β-catenin phophorylation in CF41.Mg cells, but does not affect the CF41.Mg cell apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 71125-39-8
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Molecular Weight 373.38
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Formula C14H12N3NaO4S2
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SMILES
O=C(C1=C(O[Na])C2=CC=CC=C2S(N1C)(=O)=O)NC3=NC=C(C)S3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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Neuron
2024 Nov 6;112(21):3651-3664.e8. PMID: 39241779 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
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Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Biochem Pharmacol
Transcriptome sequencing analysis reveals the molecular regulatory mechanism of myocardial hypertrophy induced by angiotensin II. [Abstract]2024 Sep 11:116532. PMID: 39270943 -
Chem Biol Interact
Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1. [Abstract]2021 Apr 1:338:109425. PMID: 33617802
Meloxicam sodium purchased from MedChemExpress. Usage Cited in: Chem Biol Interact. 2021 Apr 1:338:109425. [Abstract]
Effects of NSAIDs on hNav1.5. Effect of NSAIDs on the I–V relationship of hNav1.5 in CHO cells. I–V relationships of hNav1.5 were evoked by 100 nM of NSAIDs .
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Int Immunopharmacol
Lactate-mediated Ran lactylation at lysine 123 promotes astrocytes polarization after oxygen-glucose deprivation/reoxygenation. [Abstract]2026 Jan 1;168(Pt 2):115861. PMID: 41275824 -
Sci Rep
The key regulation of LncRNA MALAT during reprogramming of primary mouse hepatocytes into insulin producing cells. [Abstract]2025 Jul 9;15(1):24614. PMID: 40634357 -
Sci Rep
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition. [Abstract]2025 Jul 9;15(1):24789. PMID: 40634437 -
JOR Spine
M1 macrophage-derived oncostatin M induces osteogenic differentiation of ligamentum flavum cells through the JAK2/STAT3 pathway. [Abstract]2023 Oct 18;7(1):e1290. PMID: 38222812 -
Biotechnol Bioeng
An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. [Abstract]2021 Dec;118(12):4687-4698. PMID: 34478150 -
Cell Transplant
Adipose-derived stem cells inhibit dendritic cell migration by secreting tumor necrosis factor-α-stimulated gene 6 to improve the allogeneic skin transplantation survival rate in mice. [Abstract]2025 Jan-Dec:34:9636897251376125. PMID: 41108126 -
Naunyn Schmiedebergs Arch Pharmacol
Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics. [Abstract]2024 May;397(5):3313-3329. PMID: 37938371
Meloxicam sodium purchased from MedChemExpress. Usage Cited in: Naunyn Schmiedebergs Arch Pharmacol. 2024 May;397(5):3313-3329. [Abstract]
Meloxicam (0, 1, 5, 10, 15, 20 μM; 24, 48 h) shows the highest cell viability in human articular chondrocytes at 10 μM.
Purity & Documentation
References
[1]. Lazer ES, et al. Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity. J Med Chem. 1997 Mar 14;40(6):980-9. [Content Brief]
[2]. Iturriaga MP, et al. Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells. Oncol Lett. 2017 Aug;14(2):2198-2206. [Content Brief]
[3]. Fikry EM, et al. Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity. J Biochem Mol Toxicol. 2018 Feb;32(2). [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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