(+)-Balanophonin
(+)-Balanophonin is a phenolic compound that could be isolated from Passiflora edulis. (+)-Balanophonin possesses anti-oxidant, anticholinesterase, anti-inflammatory, anticancer, and antineurodegenerative activities.
For research use only. We do not sell to patients.
- CAS No.: 215319-47-4
- Formula: C20H20O6
- Molecular Weight:356.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16-4A5 | IC50 |
>100 μM
Compound: 23
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Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay
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[PMID: 20189399] |
| B16-4A5 | IC50 |
15 μM
Compound: 23
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Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells after 72 hrs
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[PMID: 20189399] |
| Hep 3B2 | IC50 |
22.4 μM
Compound: 1a
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Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
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[PMID: 29567344] |
| HepG2 | IC50 |
38.1 μM
Compound: 1a
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Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
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[PMID: 29567344] |
| Neutrophil | IC50 |
31.94 μM
Compound: 11
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Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
Antiinflammatory activity in human neutrophils assessed as fMLP-induced superoxide release after 5 mins by spectrometry
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[PMID: 17822293] |
Chemical Information
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CAS No. 215319-47-4
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Molecular Weight 356.37
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Formula C20H20O6
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SMILES
O=C/C=C/C1=CC(OC)=C(O[C@H](C2=CC=C(O)C(OC)=C2)[C@H]3CO)C3=C1.[E]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(+)-Balanophonin Related Classifications
HY-N5089 Related Classifications
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