2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. alpha-Cyperone

alpha-Cyperone  (Synonyms: α-Cyperone; (+)-α-Cyperone)

Cat. No.: HY-N0710 Purity: 99.80%
COA Handling Instructions

alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

For research use only. We do not sell to patients.

alpha-Cyperone Chemical Structure

alpha-Cyperone Chemical Structure

CAS No. : 473-08-5

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5 mg USD 60 In-stock
10 mg USD 96 In-stock
25 mg USD 216 In-stock
50 mg USD 384 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

The anti-inflammatory activity of alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2 and IL-6 via the negative regulation of the NFκB pathway in LPS-stimulated RAW 264.7 cells[1].
alpha-Cyperone (α-Cyperone) binds and interacts with tubulin and is capable of distinctly destabilizing microtubule polymerization. The effect of this interaction could result in reduction of inflammation which would be highly beneficial for treatment of inflammatory diseases such as AD. One microliter of alpha-Cyperone was dissolved in DMSO (1:1 v/v) and it was further diluted in double distilled water (ddH2O) to a final volume of 20 microliter[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

218.33

Appearance

Liquid

Formula

C15H22O
CAS No.
SMILES

O=C1C(C)=C2C[[email protected]](C(C)=C)CC[[email protected]@]2(C)CC1
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
In Vitro: 

Ethanol : 140 mg/mL (641.23 mM; Need ultrasonic)

DMSO : 100 mg/mL (458.02 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5802 mL 22.9011 mL 45.8022 mL
5 mM 0.9160 mL 4.5802 mL 9.1604 mL
10 mM 0.4580 mL 2.2901 mL 4.5802 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: 3.5 mg/mL (16.03 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: 3.5 mg/mL (16.03 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 3.5 mg/mL (16.03 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

  • 5.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

  • 6.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.45 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.80%

COA (246 KB) HNMR (243 KB) LCMS (257 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

alpha-Cyperone473-08-5α-Cyperone (+)-α-CyperoneEndogenous MetaboliteInhibitorinhibitorinhibit

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