1. Epigenetics
    PI3K/Akt/mTOR
    Apoptosis
  2. AMPK
    Apoptosis
  3. Kahweol

Kahweol 

Cat. No.: HY-N6258
Handling Instructions

Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

For research use only. We do not sell to patients.

Kahweol Chemical Structure

Kahweol Chemical Structure

CAS No. : 6894-43-5

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Description

Kahweol is one of the consituents of the coffee from Coffea Arabica with anti-inflammatory anti-angiogenic, and anti-cancerous activities. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis.

IC50 & Target

AMPK; adipogenesis; apoptosis[1]

In Vitro

Kahweol (20-40 μM; 24 hours) decreases TGF-β-induced CTGF protein expression in AML12 and LX2 cells[1].
Kahweol (20-40 μM; 1 hour) decreases TGF-β-induced phospho-Smad2/3 expression in AML12 cells, but does not affect expression in LX2 cells[1].
Kahweol (20-40 μM) significantly decreased TGF-β-stimulated phospho-ERK and JNK expression in primary hepatocytes only[1].
kahweol (0-25 μg/ml; 6-24 hours) increased the phosphorylation of AMPK and its downstream target Acetyl-CoA carboxylase (ACC) in a time-dependent manner in 3T3-L1 cells[2].
kahweol (0-25 μg/ml) significantly affects protein expression of PPARγ, C/EBPα, FABP4, and FASN, that regulate adipocyte differentiation and lipid metabolism[2].

Western Blot Analysis[2]

Cell Line: 3T3-L1 cells
Concentration: 0, 5, 10, 25 μg/ml
Incubation Time:
Result: Reduced PPARγ, C/EBPα, FABP4, and FASN expression in a dose-dependent manner.
Molecular Weight

314.42

Formula

C₂₀H₂₆O₃

CAS No.

6894-43-5

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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KeyWords:

Kahweol | AMPK | Apoptosis | AMP-activated protein kinase | Inhibitor | inhibitor | inhibit

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