2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NT-0249

NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity

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NT-0249 Chemical Structure

NT-0249 Chemical Structure

CAS No. : 2763617-39-4

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Description

NT-0249 is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity[1]

IC50 & Target

NLRP3

 

In Vivo

NT-0249 (100 mg/kg, orally, 3 times a day for 28 days) reduces systemic inflammation and astrocyte formation in mice in a pre-established obesity state[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet-Induced Obesity (DIO) in mice[1]
Dosage: 100 mg/kg
Administration: p.o. 3 times a day for 28 days
Result: Reduced inflammatory biomarkers sVCAM-1 and suPAR
Molecular Weight

481.54

Formula

C22H28N5NaO4S
CAS No.
SMILES

O=C([N-]S(N(C1=CN(C)N=C1)C[C@@H]2CCCO2)(=O)=O)NC3=C4C(CCC4)=CC5=C3CCC5.[Na+]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NT-0249 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NT-02492763617-39-4NT0249NT 0249NOD-like Receptor (NLR)NT-0796InhibitorDiet-Induced Obesity (DIO) in miceAnti-inflammatoryinhibitorinhibit

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