1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Songorine

Songorine 

Cat. No.: HY-N2080
Handling Instructions

Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC).

For research use only. We do not sell to patients.

Songorine Chemical Structure

Songorine Chemical Structure

CAS No. : 509-24-0

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Description

Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1].

IC50 & Target

IC50: GABAA receptor[1]

In Vivo

Songorine is investigated its efficacy and safety in SKOV3 tumorbearing BALB/c nude mice, songorine inhibits EOC cell survival, invasion and migration, promoted EOC cell apoptosis and suppressed mammalian EOC tumorigenic behavior. In addition, western blot and IHC results show that songorine consistently downregulates the expression of Ncadherin, vimentin, matrix metalloproteinase (MMP)2, MMP9, phosphorylated GSK3β, βcatenin and Bcl2, and upregulated the expression of Ecadherin, cleaved caspase3, cleaved caspase9 and Bax[1].
Songorine shows an Antiarrhythmic activity in aconitine-induced arrhythmia model in rats, exhibits LD50 and ED50 values of 142 mg and 7.3mg, respectively[2].

Molecular Weight

357.49

Formula

C₂₂H₃₁NO₃

CAS No.

509-24-0

SMILES
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SongorineGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAA receptorSKOV-3 tumorEpithelialovariancancerEOCantiarrhythmicantinociceptiveInhibitorinhibitorinhibit

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