509-24-0
Chemical Structure
Songorine
- CAS. Nr.: 509-24-0
- Formula:C22H31NO3
- Molecular Weight:357.49
IUPAC Name: (3R,6S,6bR,9R,11R,11aR,14R)-1-ethyl-6,11-dihydroxy-3-methyl-10-methylenedodecahydro-3,6a,12-(epiethane[1,1,2]triyl)-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one
InChIKey: CBOSLVQFGANWTL-VCKPGWDBSA-N
SMILES: O[C@@H](CC[C@]1(C)[C@@]2([H])C3)C42[C@@](CC5=O)([H])[C@@](C[C@]5([H])C6=C)([C@@H]6O)C3C4N(C1)CC
Biological Activity: Songorine is a BBB-permeable diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1][2][3].
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Songorine | 99.00% | Songorine is a BBB-permeable diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC). | ||||||||||||||||||||
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- [1]. Zhang H, et al. Songorine suppresses cell growth and metastasis in epithelial ovarian cancer via the Bcl‑2/Bax and GSK3β/β‑catenin signaling pathways.Oncol Rep. 2019 May;41(5):3069-3079. [Content Brief]
- [2]. Khan H, et al. Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum.Eur J Med Chem. 2018 Jun 10;153:29-33. [Content Brief]
- [3]. Bali ZK, et al. Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat. Pharmaceutics. 2022 Sep 28;14(10):2067. [Content Brief]
Keywords
