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  6. Deoxylimonin

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound.

For research use only. We do not sell to patients.

Deoxylimonin Chemical Structure

Deoxylimonin Chemical Structure

CAS No. : 989-23-1

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Based on 1 publication(s) in Google Scholar

Deoxylimonin Related Antibodies

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  • Purity & Documentation

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Description

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound[1].

In Vitro

Deoxylimonin (0-90 μg/mL, 48 h) treatment shows anti-proliferation activities to breast cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deoxylimonin Related Antibodies

Cell Proliferation Assay[2]

Cell Line: MDA-MB-435 and MCF-7 cells
Concentration: 0-90 μg/mL
Incubation Time: 48 hours
Result: Showed IC50 values of 0.78 μg/mL and 2.50 μg/mL for MDA-MB-435 and MCF-7 cells, respectively.
In Vivo

Deoxylimonin (oral administration; 70 mg/kg; once) treatment shows antinociception effects in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice injected with acetic acid[1]
Dosage: 70 mg/kg
Administration: Oral administration; 70 mg/kg; once
Result: Showed the antinociception efficacy (writhing inhibition rate: 24.61%).
Molecular Weight

454.51

Formula

C26H30O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@]1(C2=CC3=O)[C@@](CC[C@]2([C@@](C4=COC=C4)([H])O3)C)([H])[C@]([C@@](C5)([H])OC(C)6C)(COC5=O)[C@@]6([H])CC1=O
Structure Classification
Initial Source

Acinetobacter species
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2002 mL 11.0009 mL 22.0017 mL
5 mM 0.4400 mL 2.2002 mL 4.4003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2002 mL 11.0009 mL 22.0017 mL 55.0043 mL
5 mM 0.4400 mL 2.2002 mL 4.4003 mL 11.0009 mL
10 mM 0.2200 mL 1.1001 mL 2.2002 mL 5.5004 mL
15 mM 0.1467 mL 0.7334 mL 1.4668 mL 3.6670 mL
20 mM 0.1100 mL 0.5500 mL 1.1001 mL 2.7502 mL
25 mM 0.0880 mL 0.4400 mL 0.8801 mL 2.2002 mL
30 mM 0.0733 mL 0.3667 mL 0.7334 mL 1.8335 mL
40 mM 0.0550 mL 0.2750 mL 0.5500 mL 1.3751 mL
50 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1001 mL
60 mM 0.0367 mL 0.1833 mL 0.3667 mL 0.9167 mL
80 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6876 mL
100 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5500 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deoxylimonin989-23-1Othersanti-inflammationantinociceptionanticancerMDA-MB-435MCF-7Inhibitorinhibitorinhibit

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