Prednicarbate
Based on 1 Customer Validation
Prednicarbate is a topical corticosteroid agent. Prednicarbate can be used for the research of inflammatory skin diseases, such as atopic dermatitis.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 73771-04-7
- Formula: C27H36O8
- Molecular Weight:488.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Prednicarbate (0.25%; applied daily to the ear skin area for 2 days) recovers the 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis of mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 73771-04-7
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Appearance Solid
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Molecular Weight 488.57
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Formula C27H36O8
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Color White to off-white
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SMILES
CCC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@@]4(C(CC3)=CC(C=C4)=O)C)([H])[C@H](C2)O)([H])CC1)C)OC(OCC)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 33.33 mg/mL (68.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Lubach D, et, al. Investigation of the skin thinning effect of prednicarbate and other corticoids in mouse skin. Skin Pharmacol. 1988;1(3):200-6. [Content Brief]
[2]. Lee KH, et, al. Hizikia fusiformis fractions successfully improve atopic dermatitis indices in anti-CD3-stimulated splenocytes and 2,4-dinitrochlorobenzene-treated BALB/c mice. J Pharm Pharmacol. 2014 Mar;66(3):466-76. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0468 mL | 10.2339 mL | 20.4679 mL | 51.1697 mL |
| 5 mM | 0.4094 mL | 2.0468 mL | 4.0936 mL | 10.2339 mL | |
| 10 mM | 0.2047 mL | 1.0234 mL | 2.0468 mL | 5.1170 mL | |
| 15 mM | 0.1365 mL | 0.6823 mL | 1.3645 mL | 3.4113 mL | |
| 20 mM | 0.1023 mL | 0.5117 mL | 1.0234 mL | 2.5585 mL | |
| 25 mM | 0.0819 mL | 0.4094 mL | 0.8187 mL | 2.0468 mL | |
| 30 mM | 0.0682 mL | 0.3411 mL | 0.6823 mL | 1.7057 mL | |
| 40 mM | 0.0512 mL | 0.2558 mL | 0.5117 mL | 1.2792 mL | |
| 50 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0234 mL | |
| 60 mM | 0.0341 mL | 0.1706 mL | 0.3411 mL | 0.8528 mL |
Prednicarbate Related Classifications
HY-B1365 Related Classifications
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