2. Metabolic Enzyme/Protease Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Endogenous Metabolite Histamine Receptor
  4. Olopatadine

Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis.

For research use only. We do not sell to patients.

Olopatadine Chemical Structure

Olopatadine Chemical Structure

CAS No. : 113806-05-6

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Olopatadine Related Antibodies

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Description

Olopatadine is an orally active and selective histamine 1 (H1) receptor antagonist and a mast cell stabilizer. Olopatadine prevents immunologically stimulated pro-inflammatory mediator release from human conjunctival mast cells. Olopatadine can be used for researching allergic conjunctivitis[1][2].

IC50 & Target[1]

H1 Receptor

 

In Vitro

Olopatadine inhibits anti-IgE antibody-mediated release of TNF-α from human conjunctival mast cells, and significantly decreases the mast cell supernatant-mediated upregulation of ICAM (intercellular adhesion molecule)-1 on human conjunctival epithelial cells in vitro[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Olopatadine Related Antibodies
Clinical Trial
Molecular Weight

337.41

Formula

C21H23NO3
CAS No.
SMILES

O=C(O)CC1=CC=C(C/2=C1)OCC3=CC=CC=C3C2=C\CCN(C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Olopatadine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olopatadine113806-05-6Endogenous MetaboliteHistamine ReceptorH1mast cellallergicconjunctivitispro-inflammatoryTNF-αorally activeInhibitorinhibitorinhibit

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