2. Anti-infection
  3. Bacterial
  4. PBP10 TFA

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PBP10 TFA Chemical Structure

PBP10 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 420 In-stock
10 mg USD 670 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PBP10 TFA:

PBP10 TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE PBP10 TFA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].

IC50 & Target

IC50: formyl peptide receptor 2 (FPR2)[1]
Molecular Weight

1826.07

Formula

C86H127F3N24O17
Appearance

Solid

Color

Purple to purplish red

Sequence

RhB-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
Sequence Shortening

RhB-QRLFQVKGRR-OH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (54.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 7.14 mg/mL (3.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5476 mL 2.7381 mL 5.4762 mL
5 mM 0.1095 mL 0.5476 mL 1.0952 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (13.69 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 0.5476 mL 2.7381 mL 5.4762 mL 13.6906 mL
DMSO 5 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7381 mL
10 mM 0.0548 mL 0.2738 mL 0.5476 mL 1.3691 mL
15 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9127 mL
20 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6845 mL
25 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5476 mL
30 mM 0.0183 mL 0.0913 mL 0.1825 mL 0.4564 mL
40 mM 0.0137 mL 0.0685 mL 0.1369 mL 0.3423 mL
50 mM 0.0110 mL 0.0548 mL 0.1095 mL 0.2738 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PBP10 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBP10PBP 10PBP-10BacterialGelsolinInfammationSkin diseasesMagnetic nanoparticlesInhibitorinhibitorinhibit

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