2. GPCR/G Protein
    Neuronal Signaling
  3. Adrenergic Receptor
  4. Salmeterol

Salmeterol  (Synonyms: GR33343X)

Cat. No.: HY-14302 Purity: 99.88%
COA Handling Instructions

Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

For research use only. We do not sell to patients.

Salmeterol Chemical Structure

Salmeterol Chemical Structure

CAS No. : 89365-50-4

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10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
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Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
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100 mg USD 600 In-stock
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Based on 5 publication(s) in Google Scholar

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Description

Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

IC50 & Target[1]

β2 adrenoceptor

9.6 (pEC50)

β1 adrenoceptor

6.1 (pEC50)

β3 adrenoceptor

5.9 (pEC50)

In Vitro

Salmeterol (0.001-25 µM) inhibits human T lymphocyte proliferation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human T lymphocytes (THP-1 cells)
Concentration: 0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM
Incubation Time:
Result: The proliferation of Th2 cells was inhibited in a concentration dependent manner.
In Vivo

Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)[3]
Dosage: Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg)
Administration: The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.
Result: COPD assessment test scores were markedly improved in mice with COPD.
Clinical Trial
Molecular Weight

415.57

Appearance

Solid

Formula

C25H37NO4
CAS No.
SMILES

OC1=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (240.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4063 mL 12.0317 mL 24.0633 mL
5 mM 0.4813 mL 2.4063 mL 4.8127 mL
10 mM 0.2406 mL 1.2032 mL 2.4063 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.02 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.02 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.88%

COA (241 KB) HNMR (300 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Salmeterol89365-50-4GR33343XAdrenergic ReceptorBeta Receptorβ2agonistinflammatorycorticosteroidcombinationtherapyInhibitorinhibitorinhibit

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