1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Salmeterol xinafoate

Salmeterol xinafoate (Synonyms: GR 33343X xinafoate)

Cat. No.: HY-17453 Purity: 99.88%
Handling Instructions

Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

For research use only. We do not sell to patients.

Salmeterol xinafoate Chemical Structure

Salmeterol xinafoate Chemical Structure

CAS No. : 94749-08-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 5 publication(s) in Google Scholar

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Description

Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

IC50 & Target[1]

β2 adrenoceptor

9.6 (pEC50)

β1 adrenoceptor

6.1 (pEC50)

β3 adrenoceptor

5.9 (pEC50)

In Vitro

Salmeterol (0.001-25 µM) inhibits human T lymphocyte proliferation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human T lymphocytes (THP-1 cells)
Concentration: 0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM
Incubation Time:
Result: The proliferation of Th2 cells was inhibited in a concentration dependent manner.
In Vivo

Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)[3]
Dosage: Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg)
Administration: The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.
Result: COPD assessment test scores were markedly improved in mice with COPD.
Clinical Trial
Molecular Weight

603.75

Formula

C₃₆H₄₅NO₇

CAS No.

94749-08-3

SMILES

O=C(C1=CC=C2C=CC=CC2=C1O)O.OC3=C(CO)C=C(C(CNCCCCCCOCCCCC4=CC=CC=C4)O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (82.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6563 mL 8.2816 mL 16.5631 mL
5 mM 0.3313 mL 1.6563 mL 3.3126 mL
10 mM 0.1656 mL 0.8282 mL 1.6563 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SalmeterolGR 33343XAdrenergic ReceptorBeta Receptorβ2agonistinflammatorycorticosteroidcombinationtherapyInhibitorinhibitorinhibit

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Product Name:
Salmeterol xinafoate
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HY-17453
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