Cat. No.: HY-17453

Salmeterol xinafoate

(Synonyms: GR 33343X xinafoate)

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively.

For research use only. We do not sell to patients.

Purity: 99.88%
CAS No.: 94749-08-3
Formula: C₃₆H₄₅NO₇
Molecular Weight:603.75

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Salmeterol xinafoate Chemical Structure

CAS No.: 94749-08-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

β2 adrenoceptor

9.6 (pEC₅₀)

β1 adrenoceptor

6.1 (pEC₅₀)

β3 adrenoceptor

5.9 (pEC₅₀)

All Adrenergic Receptor Isoforms :

In Vitro

Salmeterol (0.001-25 μM) inhibits human T lymphocyte proliferation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:

Human T lymphocytes (THP-1 cells)
Concentration:

0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM
Incubation Time:
Result:

The proliferation of Th2 cells was inhibited in a concentration dependent manner.

In Vivo

Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g)^[3]
Dosage:

Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg)
Administration:

The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period.
Result:

COPD assessment test scores were markedly improved in mice with COPD.

Chemical Information

CAS No. 94749-08-3
Appearance Solid
Molecular Weight 603.75
Formula C₃₆H₄₅NO₇
Color White to off-white
SMILES

O=C(C1=CC=C2C=CC=CC2=C1O)O.OC3=C(CO)C=C(C(CNCCCCCCOCCCCC4=CC=CC=C4)O)C=C3
Synonyms

GR 33343X xinafoate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (8)

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Journal Impact Factor

Nat Commun

DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe. [Abstract]

2020 Sep 25;11(1):4857. PMID: 32978402
Neuron

Structural basis of psychedelic LSD recognition at dopamine D1 receptor. [Abstract]

2024 Jul 25:S0896-6273(24)00494-X. PMID: 39094559
Mol Ther

Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis. [Abstract]

2025 May 8:S1525-0016(25)00382-X. PMID: 40346800
J Pharm Anal

Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor. [Abstract]

2024 Jul;14(7):100934. PMID: 39139999

Salmeterol xinafoate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2024 Jul;14(7):100934. [Abstract]

MDA-MB-231 and 4T1 cells were treated with BA, isoproterenol (ISO)/Salmeterol (SAL), or BA plus ISO/SAL, and the intracellular cyclic adenosine monophosphate (cAMP) level was detected.

Salmeterol xinafoate purchased from MedChemExpress. Usage Cited in: J Pharm Anal. 2024 Jul;14(7):100934. [Abstract]

The protein expression levels of EMT markers (E-cadherin, N-cadherin, MMP2, and vimentin) were detected in 4T1 cells treated with BA, Salmeterol (SAL), or SAL combined with BA.
Cell Rep

Structural Basis of the Diversity of Adrenergic Receptors. [Abstract]

2019 Dec 3;29(10):2929-2935.e4 PMID: 31801060
Neurobiol Dis

Neonatal therapy with clenbuterol and salmeterol restores spinogenesis and dendritic complexity in the dentate gyrus of the Ts65Dn model of Down syndrome. [Abstract]

2020 Jul;140:104874. PMID: 32325119
J Pharm Biomed Anal

Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]

2021 Feb 20:195:113870. PMID: 33453569
Drug Test Anal

High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]

2021 Feb;13(2):283-298. PMID: 32852861

Solvent & Solubility

In Vitro:

DMSO : ≥ 50 mg/mL (82.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6563 mL

8.2816 mL

16.5631 mL

5 mM

0.3313 mL

1.6563 mL

3.3126 mL

10 mM

0.1656 mL

0.8282 mL

1.6563 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Panayiotis A Procopiou, et al. The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating a urea group. Bioorg Med Chem. 2011 Oct 15;19(20):6026-32. [Content Brief]

[2]. Malcolm Johnson. Effects of beta2-agonists on resident and infiltrating inflammatory cells. J Allergy Clin Immunol. 2002 Dec;110(6 Suppl):S282-90. [Content Brief]

[3]. Zhiyuan Wang, et al. Efficacy of salmeterol and formoterol combination treatment in mice with chronic obstructive pulmonary disease. Exp Ther Med. 2018 Feb;15(2):1538-1545. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6563 mL	8.2816 mL	16.5631 mL	41.4079 mL
	5 mM	0.3313 mL	1.6563 mL	3.3126 mL	8.2816 mL
	10 mM	0.1656 mL	0.8282 mL	1.6563 mL	4.1408 mL
	15 mM	0.1104 mL	0.5521 mL	1.1042 mL	2.7605 mL
	20 mM	0.0828 mL	0.4141 mL	0.8282 mL	2.0704 mL
	25 mM	0.0663 mL	0.3313 mL	0.6625 mL	1.6563 mL
	30 mM	0.0552 mL	0.2761 mL	0.5521 mL	1.3803 mL
	40 mM	0.0414 mL	0.2070 mL	0.4141 mL	1.0352 mL
	50 mM	0.0331 mL	0.1656 mL	0.3313 mL	0.8282 mL
	60 mM	0.0276 mL	0.1380 mL	0.2761 mL	0.6901 mL
	80 mM	0.0207 mL	0.1035 mL	0.2070 mL	0.5176 mL

Keywords

Salmeterol xinafoate

8 Cited Publications

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Salmeterol xinafoate

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Publications Citing Use of MedChemExpress (MCE) Salmeterol xinafoate

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Salmeterol xinafoate Related Classifications

HY-17453 Related Classifications