1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Glycopyrrolate

Glycopyrrolate (Synonyms: Glycopyrronium bromide; Glycopyrrolate bromide)

Cat. No.: HY-17465 Purity: 98.55%
Handling Instructions

Glycopyrrolate (Glycopyrronium bromide) is a muscarinic competitive antagonist used as an antispasmodic.

For research use only. We do not sell to patients.

Glycopyrrolate Chemical Structure

Glycopyrrolate Chemical Structure

CAS No. : 596-51-0

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 108 In-stock
Estimated Time of Arrival: December 31
100 mg USD 156 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Glycopyrrolate (Glycopyrronium bromide) is a muscarinic competitive antagonist used as an antispasmodic. IC50 Value: Target: mAChR (Muscarinic acetylcholine receptor M1) in vitro: Glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Kinetics studies, however, showed that glycopyrrolate dissociates slowly from HASM muscarinic receptors (60% protection against [3H]-NMS binding at 30 nM) compared to ipratropium bromide [1]. in vivo: Glycopyrrolate (1 mg) tablets were then administered, starting with one tablet daily the third week and increasing the daily dose by one tablet per week until a maximum of four tablets during week six and 4 days of week seven when the daily dose was reduced to two tablets for 3 days. glycopyrrolate can be given in controlled doses provided that an adequate medical assessment has been undertaken [2]. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect [3]. Oral glycopyrrolate is emerging as a potential second-line treatment option, but experience with safety, efficacy, and dosing is especially limited in children [4]. phase III study, 52.3% of glycopyrrolate oral solution recipients (aged 3-18 years; n = 137) had an mTDS response (primary endpoint); the response rate was consistently above 50% at all 4-weekly timepoints, aside from the first assessment at week 4 (40.3%). In general, glycopyrrolate oral solution was well tolerated in clinical trials. The majority of adverse events were within expectations as characteristic anticholinergic outcomes [5]. Toxicity: Side effects include dry mouth, difficult urinating, heachaches, diarrhea and constipation. The medication also induces drowsiness or blurred vision. LD50=709 mg/kg (rat, oral).

Clinical Trial
Molecular Weight

398.33

Formula

C₁₉H₂₈BrNO₃

CAS No.

596-51-0

SMILES

C[N+]1(C)CC(OC(C(O)(C2CCCC2)C3=CC=CC=C3)=O)CC1.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 45 mg/mL (112.97 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5105 mL 12.5524 mL 25.1048 mL
5 mM 0.5021 mL 2.5105 mL 5.0210 mL
10 mM 0.2510 mL 1.2552 mL 2.5105 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

GlycopyrrolateGlycopyrroniummAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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Glycopyrrolate
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