1. GPCR/G Protein
  2. Adrenergic Receptor

Indacaterol maleate 

Cat. No.: HY-14299A Purity: 99.92%
Handling Instructions

Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.

For research use only. We do not sell to patients.

Indacaterol maleate Chemical Structure

Indacaterol maleate Chemical Structure

CAS No. : 753498-25-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 125 In-stock
Estimated Time of Arrival: December 31
100 mg USD 114 In-stock
Estimated Time of Arrival: December 31
500 mg USD 318 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Other Forms of Indacaterol maleate:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist. Target: β-adrenoceptor Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium [1]. Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways [2]. Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey [1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9663 mL 9.8317 mL 19.6634 mL
5 mM 0.3933 mL 1.9663 mL 3.9327 mL
10 mM 0.1966 mL 0.9832 mL 1.9663 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

508.56

Formula

C₂₈H₃₂N₂O₇

CAS No.

753498-25-8

SMILES

O=C1NC2=C(C([[email protected]@H](O)CNC3CC4=C(C=C(CC)C(CC)=C4)C3)=CC=C2O)C=C1.O=C(O)/C=C\C(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.92%

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Product Name:
Indacaterol maleate
Cat. No.:
HY-14299A
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Indacaterol maleate

Cat. No.: HY-14299A