1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Indacaterol maleate

Indacaterol maleate (Synonyms: QAB149)

Cat. No.: HY-14299A Purity: 99.92%
Handling Instructions

Indacaterol (QAB149) maleate is an ultra-long-acting β-adrenoceptor agonist.

For research use only. We do not sell to patients.

Indacaterol maleate Chemical Structure

Indacaterol maleate Chemical Structure

CAS No. : 753498-25-8

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10 mM * 1 mL in DMSO USD 125 In-stock
Estimated Time of Arrival: December 31
100 mg USD 114 In-stock
Estimated Time of Arrival: December 31
500 mg USD 318 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Indacaterol maleate:

Top Publications Citing Use of Products
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Description

Indacaterol (QAB149) maleate is an ultra-long-acting β-adrenoceptor agonist.

IC50 & Target

β-adrenoceptor[1].

In Vivo

Indacaterol (QAB149) inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol (QAB149) inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium[1]. Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways[2]. Indacaterol (QAB149) (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (QAB149) (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey[1].

Clinical Trial
Molecular Weight

508.56

Formula

C₂₈H₃₂N₂O₇

CAS No.

753498-25-8

SMILES

O=C1NC2=C(C([[email protected]@H](O)CNC3CC4=C(C=C(CC)C(CC)=C4)C3)=CC=C2O)C=C1.O=C(O)/C=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (196.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9663 mL 9.8317 mL 19.6634 mL
5 mM 0.3933 mL 1.9663 mL 3.9327 mL
10 mM 0.1966 mL 0.9832 mL 1.9663 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.09 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.92%

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Keywords:

IndacaterolQAB149QAB 149QAB-149Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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Indacaterol maleate
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HY-14299A
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