1. GPCR/G Protein
  2. Adrenergic Receptor

Indacaterol maleate 

Cat. No.: HY-14299A Purity: 95.60%
Data Sheet SDS Handling Instructions

Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist.

For research use only. We do not sell to patients.
Indacaterol maleate Chemical Structure

Indacaterol maleate Chemical Structure

CAS No. : 753498-25-8

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10 mM * 1 mL in DMSO $105 In-stock
100 mg $95 In-stock
500 mg $265 In-stock
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Other Forms of Indacaterol maleate:

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Description

Indacaterol Maleate is an ultra-long-acting β-adrenoceptor agonist. Target: β-adrenoceptor Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium [1]. Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways [2]. Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey [1].

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References
Molecular Weight

508.56

Formula

C₂₈H₃₂N₂O₇

CAS No.

753498-25-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Indacaterol maleate
Cat. No.:
HY-14299A
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