Arformoterol tartrate
Based on 1 publication(s) in Google Scholar
Arformoterol ((R,R)-Formoterol) tartrate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol tartrate can be used for the research of chronic obstructive pulmonary disease (COPD).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.63%
- CAS No.: 200815-49-2
- Formule: C23H30N2O10
- Masse moléculaire:494.49
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Arformoterol tartrate
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Activité biologique
Description
IC50 & Target
[1]|
Beta-2 adrenergic receptor 2.9 nM (Kd) |
In Vitro
Arformoterol tartrate induces cAMP accumulation in cultured human bronchial epithelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
Arformoterol tartrate reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s=1 and 40 nmol/kg, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type and iNOS−/− mice were exposed to Cl2 gas[3]
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Dosage:10 ng in 0.1 ml saline/20 g body weight
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Administration:Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
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Result:Significantly mitigated the Cl2-induced increases of respiratory system resistance and elastance.
Increased cAMP in the lungs of Cl2-exposed mice.
Not mitigated Cl2-induced lung injury and inflammation.
Chemical Information
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CAS No. 200815-49-2
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Appearance Solid
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Masse moléculaire 494.49
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Formule C23H30N2O10
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Color White to off-white
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SMILES
OC1=CC=C([C@@H](O)CN[C@H](C)CC2=CC=C(OC)C=C2)C=C1NC=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O
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Synonyms
(R,R)-Formoterol tartrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (101.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (50.56 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15(2):135-45. [Content Brief]
[2]. Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4(2):155-62. [Content Brief]
[3]. Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45(1):88-94. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.0223 mL | 10.1114 mL | 20.2229 mL | 50.5571 mL |
| 5 mM | 0.4045 mL | 2.0223 mL | 4.0446 mL | 10.1114 mL | |
| 10 mM | 0.2022 mL | 1.0111 mL | 2.0223 mL | 5.0557 mL | |
| 15 mM | 0.1348 mL | 0.6741 mL | 1.3482 mL | 3.3705 mL | |
| 20 mM | 0.1011 mL | 0.5056 mL | 1.0111 mL | 2.5279 mL | |
| 25 mM | 0.0809 mL | 0.4045 mL | 0.8089 mL | 2.0223 mL | |
| 30 mM | 0.0674 mL | 0.3370 mL | 0.6741 mL | 1.6852 mL | |
| 40 mM | 0.0506 mL | 0.2528 mL | 0.5056 mL | 1.2639 mL | |
| 50 mM | 0.0404 mL | 0.2022 mL | 0.4045 mL | 1.0111 mL | |
| DMSO | 60 mM | 0.0337 mL | 0.1685 mL | 0.3370 mL | 0.8426 mL |
| 80 mM | 0.0253 mL | 0.1264 mL | 0.2528 mL | 0.6320 mL | |
| 100 mM | 0.0202 mL | 0.1011 mL | 0.2022 mL | 0.5056 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Arformoterol tartrate Related Classifications
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