Arformoterol maleate  (Synonyms: (R,R)-Formoterol maleate)

Arformoterol ((R,R)-Formoterol) maleate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a K_d of 2.9 nM. Arformoterol maleate can be used for the research of chronic obstructive pulmonary disease (COPD)^[1][2].

Arformoterol maleate induces cAMP accumulation in cultured human bronchial epithelial cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Arformoterol (10 ng in 0.1 ml saline/20 g body weight; intranasal instillation) maleate mitigates Cl₂-induced increases of respiratory system resistance and elastance in mice^[3].
Arformoterol maleate reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED₅₀s=1 and 40 nmol/kg, respectively)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

460.48

C₂₃H₂₈N₂O₈

1254575-18-2

OC1=CC=C([C@@H](O)CN[C@H](C)CC2=CC=C(OC)C=C2)C=C1NC=O.O=C(/C=C\C(O)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15(2):135-45.  [Content Brief]

  [2]. Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4(2):155-62.  [Content Brief]

  [3]. Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45(1):88-94.  [Content Brief]