Arformoterol maleate
Based on 1 publication(s) in Google Scholar
Arformoterol ((R,R)-Formoterol) maleate, the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol maleate can be used for the research of chronic obstructive pulmonary disease (COPD).
For research use only. We do not sell to patients.
- CAS No.: 1254575-18-2
- Formula: C23H28N2O8
- Molecular Weight:460.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Arformoterol maleate
MoreAll Adrenergic Receptor Isoforms
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Biological Activity
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Beta-2 adrenergic receptor 2.9 nM (Kd) |
Arformoterol maleate induces cAMP accumulation in cultured human bronchial epithelial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Arformoterol maleate reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s=1 and 40 nmol/kg, respectively)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wild-type and iNOS−/− mice were exposed to Cl2 gas[3]
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Dosage:10 ng in 0.1 ml saline/20 g body weight
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Administration:Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
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Result:Significantly mitigated the Cl2-induced increases of respiratory system resistance and elastance.
Increased cAMP in the lungs of Cl2-exposed mice.
Not mitigated Cl2-induced lung injury and inflammation.
Chemical Information
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CAS No. 1254575-18-2
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Molecular Weight 460.48
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Formula C23H28N2O8
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SMILES
OC1=CC=C([C@@H](O)CN[C@H](C)CC2=CC=C(OC)C=C2)C=C1NC=O.O=C(/C=C\C(O)=O)O
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Synonyms
(R,R)-Formoterol maleate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569
Purity & Documentation
References
[1]. Handley DA, et, al. Biological actions of formoterol isomers. Pulm Pharmacol Ther. 2002;15(2):135-45. [Content Brief]
[2]. Cazzola M, et, al. Arformoterol tartrate in the treatment of COPD. Expert Rev Respir Med. 2010 Apr;4(2):155-62. [Content Brief]
[3]. Song W, et, al. Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am J Respir Cell Mol Biol. 2011 Jul;45(1):88-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Arformoterol maleate Related Classifications
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