(S,S)-Formoterol
Based on 1 Customer Validation
(S,S)-Formoterol ((+)-Formoterol) is the (S,S)-enantiomer of Formoterol (HY-B0010B). (S,S)-Formoterol is a β2-adrenergic receptor (β2-adrenergic receptor) ligand. (S,S)-Formoterol can induce mast cell mediator release, peribronchial and perivascular inflammatory cell infiltration, basal airway tone, IFN-γ production, and IL-4 production. (S,S)-Formoterol acts through the β2-adrenergic receptor, altering its transduction pathways and modulating receptor structure and function. (S,S)-Formoterol can be used in the study of asthma.
For research use only. We do not sell to patients.
- Purity : 95.83%
- CAS No.: 67346-48-9
- Formula: C19H24N2O4
- Molecular Weight:344.40
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
All Adrenergic Receptor Isoforms
More
Biological Activity
Description
|
IL-4 |
β2-adrenergic receptor |
IFN-γ |
In Vitro
(S,S)-Formoterol (10-7 M) enhances IL-4 production in PMA/A23187-stimulated HMC-1 human mast cells[1].
(S,S)-Formoterol (10-9 to 10-6 M; 10 min) enhances IL-4 production in IgE/DNP-stimulated C1.MC/C57.1 murine mast cells in a dose-dependent manner[1].
(S,S)-Formoterol (10-7 M; 10 min) enhances histamine and PGD2 secretion in IgE/DNP-stimulated C1.MC/C57.1 murine mast cells[1].
(S,S)-Formoterol (10-7 M) does not affect IL-4 secretion in PMA-stimulated Jurkat T cells[1].
(S,S)-Formoterol (10-7 M; 24 hours) significantly stimulates IFN-γ and IL-4 production in tetanus-specific T-cell lines, while having no significant effect on IL-2, IL-5, IL-13, or GM-CSF[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
-
Cell Line:C1.MC/C57.1
-
Concentration:1 nM; 10 nM; 100 nM; 1 μM
-
Incubation Time:10 min
-
Result:Increased IL-4 secretion by 70% relative to untreated stimulated cells (44.7 vs. 26.3 pg/mL; n = 5).
Enhanced IL-4 production in a dose-dependent manner compared with untreated stimulated cells (n = 5).
-
Cell Line:C1.MC/C57.1
-
Concentration:100 nM
-
Incubation Time:10 min
-
Result:Increased histamine release by 13% relative to untreated IgE-stimulated cells (51.2 vs. 39.4%; n = 4).
Increased PGD2 secretion by 57% relative to untreated IgE-stimulated cells (9.1 vs. 5.8 ng/mL; n = 4).
-
Cell Line:Tetanus-specific T-cell lines
-
Concentration:100 nM
-
Incubation Time:24 hours
-
Result:Stimulated IFN-γ production to 783 pg/mL vs control 563 pg/mL.
Stimulated IL-4 production to 15.4 pg/mL vs control 12.3 pg/mL.
Resulted in IL-2 levels of 1585 pg/mL, IL-13 levels of 133 pg/mL, IL-5 levels of 37.4 pg/mL, and GM-CSF levels of 168 pg/mL.
Chemical Information
-
CAS No. 67346-48-9
-
Appearance Solid
-
Molecular Weight 344.40
-
Formula C19H24N2O4
-
Color Light brown to brown
-
SMILES
O=CNC1=CC([C@H](O)CN[C@@H](C)CC2=CC=C(OC)C=C2)=CC=C1O
-
Synonyms
(+)-Formoterol
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (145.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9036 mL | 14.5180 mL | 29.0360 mL | 72.5900 mL |
| 5 mM | 0.5807 mL | 2.9036 mL | 5.8072 mL | 14.5180 mL | |
| 10 mM | 0.2904 mL | 1.4518 mL | 2.9036 mL | 7.2590 mL | |
| 15 mM | 0.1936 mL | 0.9679 mL | 1.9357 mL | 4.8393 mL | |
| 20 mM | 0.1452 mL | 0.7259 mL | 1.4518 mL | 3.6295 mL | |
| 25 mM | 0.1161 mL | 0.5807 mL | 1.1614 mL | 2.9036 mL | |
| 30 mM | 0.0968 mL | 0.4839 mL | 0.9679 mL | 2.4197 mL | |
| 40 mM | 0.0726 mL | 0.3630 mL | 0.7259 mL | 1.8148 mL | |
| 50 mM | 0.0581 mL | 0.2904 mL | 0.5807 mL | 1.4518 mL | |
| 60 mM | 0.0484 mL | 0.2420 mL | 0.4839 mL | 1.2098 mL | |
| 80 mM | 0.0363 mL | 0.1815 mL | 0.3630 mL | 0.9074 mL | |
| 100 mM | 0.0290 mL | 0.1452 mL | 0.2904 mL | 0.7259 mL |
(S,S)-Formoterol Related Classifications
HY-B0010C Related Classifications
Powered by Bioz
Keywords
- (S,S)-Formoterol
- 67346-48-9
- (+)-Formoterol
- Interleukin Related
- Adrenergic Receptor
- IFNAR
- HMC-1 human mast cells
- IL-4 production
- tetanus-specific T-cell lines
- mast cell mediator release
- C1.MC/C57.1 murine mast cells
- β2-adrenergic receptor
- murine asthma model
- T-cell proliferation
- peribronchial and perivascular inflammatory cell infiltration
- IFN-γ production
- Inhibitor
- inhibitor
- inhibit