Formoterol
Based on 7 publication(s) in Google Scholar
Formoterol ((±)Formoterol) is a selective β2-adrenoceptor agonist. Formoterol is at least as β2-adrenoceptor selective as Salbutamol (HY-B1037) and Terbutaline (HY-B0802A). Formoterol abolishs the contraction induced by Acetylcholine in bronchioles. Formoterol can be used for the research of chronic obstructive pulmonary disease and bronchial asthma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.31%
- CAS 番号: 73573-87-2
- 分子式: C19H24N2O4
- 分子量:344.40
-
保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
MedChemExpress(MCE)の使用を引用している文献 Formoterol
More- Nat Commun. 2024 Nov 28;15(1):10361. [Abstract]
- J Neuroinflammation. 2025 Dec 8. [Abstract]
- Inflammation. 2026 Jan 15;49(1):48. [Abstract]
- J Enzyme Inhib Med Chem. 2025 Dec;40(1):2501743. [Abstract]
- Chem Biol Interact. 2025 Sep 4:111724. [Abstract]
- Immun Inflamm Dis. 2024 Nov;12(11):e70073. [Abstract]
- Fundam Clin Pharmacol. 2024 Dec;38(6):1116-1130. [Abstract]
-
Histological Imaging/Staining
-
Bio/Physico-chemical Assay
-
In Vivo Efficacy Study
-
RT-PCR
-
In Vivo Efficacy Study
Adrenergic Receptor アイソフォーム固有の製品をすべて表示
More
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
0.19 nM
Compound: 1
|
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
|
[PMID: 21310610] |
体外実験
Formoterol (5-15 min intervals) potently and completely relaxes acetylcholine-pre-contracted human isolated segmental bronchi with a pEC50 of 8.76[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 73573-87-2
-
性状 Solid
-
分子量 344.40
-
分子式 C19H24N2O4
-
Color White to off-white
-
SMILES
O=CNC1=CC([C@H](O)CN[C@@H](C)CC2=CC=C(OC)C=C2)=CC=C1O
-
別名
(±)Formoterol
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (7)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice. [Abstract]2024 Nov 28;15(1):10361. PMID: 39609433
Formoterol purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 28;15(1):10361. [Abstract]
The liver/body weight ratios of Formoterol fumarate (FORM, 1 mg/kg; i.p.; once daily for 21 days) +PHx mice are significantly decreased than that of Vehicle+PHx mice (n=6 mice).
Formoterol purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 28;15(1):10361. [Abstract]
The mRNA expression levels of Ki67 and Pcna of Formoterol fumarate (FORM, 1 mg/kg; i.p.; once daily for 21 days) +PHx mice are significantly decreased than that of Vehicle+PHx mice (n=6 mice).
-
J Neuroinflammation
Hyperglycemia impairs microglia responding to retinal vasculopathy via enhanced norepinephrine-ADRB2 signaling. [Abstract]2025 Dec 8. PMID: 41361454
Formoterol purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Dec 8. [Abstract]
Time‑lapse images depicting microglial process convergence toward vessel injury in retinas pretreated with Formoterol fumarate (2 μM; 30 min).
-
Inflammation
Activation of β2-Adrenergic Receptor Alleviates Viral Myocarditis by Regulating Energy Metabolism in Monocyte-derived Macrophages via the AMPK Pathway. [Abstract]2026 Jan 15;49(1):48. PMID: 41537900
Formoterol purchased from MedChemExpress. Usage Cited in: Inflammation. 2026 Jan 15;49(1):48. [Abstract]
Representative H&E staining of the myocardium from the Vehicle, Lipo-Clod, Formoterol fumarate (0.3 mg/kg; i.p.; once a day for 2 weeks), and Formoterol fumarate + Lipo-Clod groups at 1 week and 2 weeks post-CVB3 infection (original magnification, 200× ; scale bars = 50 μm).
-
J Enzyme Inhib Med Chem
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]2025 Dec;40(1):2501743. PMID: 40371698 -
Chem Biol Interact
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury. [Abstract]2025 Sep 4:111724. PMID: 40914538 -
Immun Inflamm Dis
Formoterol Reduces the Pro-Inflammatory Phenotype by Enhancing the Activity of Glutaminase in Monocyte-Derived Macrophages in the CVB3-Induced Viral Myocarditis. [Abstract]2024 Nov;12(11):e70073. PMID: 39601476
Formoterol purchased from MedChemExpress. Usage Cited in: Immun Inflamm Dis. 2024 Nov;12(11):e70073. [Abstract]
Formoterol fumarate (0.3 mg/kg; i.p.; once a day for 2 weeks). Representative images of mouse hearts in each group after CVB3 infection for 1 week or 2 weeks.
-
Fundam Clin Pharmacol
The β2-adrenergic receptor agonist formoterol attenuates necrosis and apoptosis in the rat myocardium under experimental stress-induced cardiac injury. [Abstract]2024 Dec;38(6):1116-1130. PMID: 38956972
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (725.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (270 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9036 mL | 14.5180 mL | 29.0360 mL | 72.5900 mL |
| 5 mM | 0.5807 mL | 2.9036 mL | 5.8072 mL | 14.5180 mL | |
| 10 mM | 0.2904 mL | 1.4518 mL | 2.9036 mL | 7.2590 mL | |
| 15 mM | 0.1936 mL | 0.9679 mL | 1.9357 mL | 4.8393 mL | |
| 20 mM | 0.1452 mL | 0.7259 mL | 1.4518 mL | 3.6295 mL | |
| 25 mM | 0.1161 mL | 0.5807 mL | 1.1614 mL | 2.9036 mL | |
| 30 mM | 0.0968 mL | 0.4839 mL | 0.9679 mL | 2.4197 mL | |
| 40 mM | 0.0726 mL | 0.3630 mL | 0.7259 mL | 1.8148 mL | |
| 50 mM | 0.0581 mL | 0.2904 mL | 0.5807 mL | 1.4518 mL | |
| 60 mM | 0.0484 mL | 0.2420 mL | 0.4839 mL | 1.2098 mL | |
| 80 mM | 0.0363 mL | 0.1815 mL | 0.3630 mL | 0.9074 mL | |
| 100 mM | 0.0290 mL | 0.1452 mL | 0.2904 mL | 0.7259 mL |