Formoterol hemifumarate hydrate
Based on 7 publication(s) in Google Scholar
Formoterol hemifumarate hydrate is a selective, long-acting beta 2-adrenoceptor agonist. Formoterol is a bronchodilator used for the research of the asthma and chronic obstructive pulmonary disease (COPD). Formoterol hemifumarate hydrate induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 183814-30-4
- Formula: C19H24N2O4.1/2C4H4O4.H2O
- Molecular Weight:840.91
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Formoterol hemifumarate hydrate
More- Nat Commun. 2024 Nov 28;15(1):10361. [Abstract]
- J Neuroinflammation. 2025 Dec 8. [Abstract]
- Inflammation. 2026 Jan 15;49(1):48. [Abstract]
- J Enzyme Inhib Med Chem. 2025 Dec;40(1):2501743. [Abstract]
- Chem Biol Interact. 2025 Sep 4:111724. [Abstract]
- Immun Inflamm Dis. 2024 Nov;12(11):e70073. [Abstract]
- Fundam Clin Pharmacol. 2024 Dec;38(6):1116-1130. [Abstract]
Customer Validation & Images
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Histological Imaging/Staining
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
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RT-PCR
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In Vivo Efficacy Study
All Adrenergic Receptor Isoforms
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Biological Activity
Chemical Information
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CAS No. 183814-30-4
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Appearance Solid
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Molecular Weight 840.91
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Formula C19H24N2O4.1/2C4H4O4.H2O
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Color White to off-white
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SMILES
OC(/C=C/C(O)=O)=O.COC(C=C1)=CC=C1C[C@H](C)NC[C@H](C2=CC(NC=O)=C(C=C2)O)O.O.[1/2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Nat Commun
A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice. [Abstract]2024 Nov 28;15(1):10361. PMID: 39609433
Formoterol hemifumarate hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 28;15(1):10361. [Abstract]
The liver/body weight ratios of Formoterol fumarate (FORM, 1 mg/kg; i.p.; once daily for 21 days) +PHx mice are significantly decreased than that of Vehicle+PHx mice (n=6 mice).
Formoterol hemifumarate hydrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Nov 28;15(1):10361. [Abstract]
The mRNA expression levels of Ki67 and Pcna of Formoterol fumarate (FORM, 1 mg/kg; i.p.; once daily for 21 days) +PHx mice are significantly decreased than that of Vehicle+PHx mice (n=6 mice).
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J Neuroinflammation
Hyperglycemia impairs microglia responding to retinal vasculopathy via enhanced norepinephrine-ADRB2 signaling. [Abstract]2025 Dec 8. PMID: 41361454
Formoterol hemifumarate hydrate purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Dec 8. [Abstract]
Time‑lapse images depicting microglial process convergence toward vessel injury in retinas pretreated with Formoterol fumarate (2 μM; 30 min).
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Inflammation
Activation of β2-Adrenergic Receptor Alleviates Viral Myocarditis by Regulating Energy Metabolism in Monocyte-derived Macrophages via the AMPK Pathway. [Abstract]2026 Jan 15;49(1):48. PMID: 41537900
Formoterol hemifumarate hydrate purchased from MedChemExpress. Usage Cited in: Inflammation. 2026 Jan 15;49(1):48. [Abstract]
Representative H&E staining of the myocardium from the Vehicle, Lipo-Clod, Formoterol fumarate (0.3 mg/kg; i.p.; once a day for 2 weeks), and Formoterol fumarate + Lipo-Clod groups at 1 week and 2 weeks post-CVB3 infection (original magnification, 200× ; scale bars = 50 μm).
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J Enzyme Inhib Med Chem
Natural product sennoside B disrupts liquid-liquid phase separation of SARS-CoV-2 nucleocapsid protein by inhibiting its RNA-binding activity. [Abstract]2025 Dec;40(1):2501743. PMID: 40371698 -
Chem Biol Interact
Formoterol, a clinically approved drug, inhibits ferroptosis by suppressing lipid peroxidation and attenuates APAP-induced acute liver injury. [Abstract]2025 Sep 4:111724. PMID: 40914538 -
Immun Inflamm Dis
Formoterol Reduces the Pro-Inflammatory Phenotype by Enhancing the Activity of Glutaminase in Monocyte-Derived Macrophages in the CVB3-Induced Viral Myocarditis. [Abstract]2024 Nov;12(11):e70073. PMID: 39601476
Formoterol hemifumarate hydrate purchased from MedChemExpress. Usage Cited in: Immun Inflamm Dis. 2024 Nov;12(11):e70073. [Abstract]
Formoterol fumarate (0.3 mg/kg; i.p.; once a day for 2 weeks). Representative images of mouse hearts in each group after CVB3 infection for 1 week or 2 weeks.
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Fundam Clin Pharmacol
The β2-adrenergic receptor agonist formoterol attenuates necrosis and apoptosis in the rat myocardium under experimental stress-induced cardiac injury. [Abstract]2024 Dec;38(6):1116-1130. PMID: 38956972
Solvent & Solubility
DMSO : 125 mg/mL (148.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. Bartow RA, et al. An update of its pharmacological properties and therapeutic efficacy in the management of asthma [published correction appears in Drugs 1998 Apr;55(4):517]. Drugs. 1998;55(2):303-322. [Content Brief]
[2]. Tashkin DP. Formoterol for the Treatment of Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2020;15:3105-3122. Published 2020 Nov 27. [Content Brief]
[3]. Vekaria HJ, et al. Formoterol, a β2-adrenoreceptor agonist, induces mitochondrial biogenesis and promotes cognitive recovery after traumatic brain injury. Neurobiol Dis. 2020;140:104866. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1892 mL | 5.9459 mL | 11.8919 mL | 29.7297 mL |
| 5 mM | 0.2378 mL | 1.1892 mL | 2.3784 mL | 5.9459 mL | |
| 10 mM | 0.1189 mL | 0.5946 mL | 1.1892 mL | 2.9730 mL | |
| 15 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9820 mL | |
| 20 mM | 0.0595 mL | 0.2973 mL | 0.5946 mL | 1.4865 mL | |
| 25 mM | 0.0476 mL | 0.2378 mL | 0.4757 mL | 1.1892 mL | |
| 30 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9910 mL | |
| 40 mM | 0.0297 mL | 0.1486 mL | 0.2973 mL | 0.7432 mL | |
| 50 mM | 0.0238 mL | 0.1189 mL | 0.2378 mL | 0.5946 mL | |
| 60 mM | 0.0198 mL | 0.0991 mL | 0.1982 mL | 0.4955 mL | |
| 80 mM | 0.0149 mL | 0.0743 mL | 0.1486 mL | 0.3716 mL | |
| 100 mM | 0.0119 mL | 0.0595 mL | 0.1189 mL | 0.2973 mL |
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