Cat. No.: HY-B0661A

Tamsulosin hydrochloride

(Synonyms: (R)-(-)-YM12617; LY253351)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α₁-adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models.

For research use only. We do not sell to patients.

Purity: 99.76%
CAS No.: 106463-17-6
Formula: C₂₀H₂₉ClN₂O₅S
Molecular Weight:444.97

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Tamsulosin hydrochloride Chemical Structure

CAS No.: 106463-17-6

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

α1-adrenergic receptor

All Adrenergic Receptor Isoforms :

In Vitro

Tamsulosin hydrochloride shows intrinsic activity at human alpha1B adrenergic receptor expressed in CHOK1 cells co-expressing aequorin, with EC₅₀ of 0.13 nM^[2].
Tamsulosin (25-50 nM, 24 h) hydrochloride attenuates high glucose-induced injury in glomerular endothelial cells^[3].
Tamsulosin (1-100 μM, 5 days) hydrochloride significantly influences ECM production and distribution as well as cellular metabolism levels in ARPE 19 cells in a concentration-dependent manner^[4].
. Tamsulosin (50-400 μM, 24 h) hydrochloride induces apoptosis and clusterin expression in NRP-152 cells^[5].
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR ^[3]

Cell Line:

Human glomerular endothelial cells (GECs)
Concentration:

25, and 50 nM
Incubation Time:

24 h
Result:

Attenuated high glucose-induced expression of pro-inflammatory cytokines IL-6, TNF-α, and IL-8.
Reduced MMP-2 and MMP-9.
Prevented high glucose-induced expression of VCAM-1 and ICAM-1.
Decreased Col-1 and TGF-β1.

Western Blot Analysis ^[3]

Cell Line:

Human glomerular endothelial cells (GECs)
Concentration:

25, and 50 nM
Incubation Time:

24 h
Result:

Decreased nuclear NF-κB p65 to 2.7- and 1.9- fold at 25 and 50 nM, respectively.

In Vivo

Tamsulosin (0.001-1 mg/kg, gavage, subacutely, 3 doses within 24 h (1, 5 and 23 h) or acutely 60 min before the behavioral tests) hydrochloride facilitates depressive-like behaviors through endogenous glucocorticoids in mice^[6].
Tamsulosin (0.01-1 mg/kg, p.o., once a day for 14 consecutive days) hydrochloride exerts inhibitory effect on neuronal activation in the voiding centers of rats with Cyclophosphamide (HY-17420)-induced overactive bladder^[7].
Tamsulosin (17.5-35 mcg/kg/d, p.o.) hydrochloride results in protection from respiratory inflammatory events in rats with induced airway sensitization^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 106463-17-6
Appearance Solid
Molecular Weight 444.97
Formula C₂₀H₂₉ClN₂O₅S
Color White to off-white
SMILES

O=S(C1=CC(C[C@H](NCCOC2=CC=CC=C2OCC)C)=CC=C1OC)(N)=O.Cl
Synonyms

(R)-(-)-YM12617; LY253351
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (2)

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Journal Impact Factor

Nat Commun

A gatekeeper sympathetic control of lacrimal tear secretion and dry eye onset through the NA-Adra1a-Ucp2 pathway. [Abstract]

2025 Jun 5;16(1):5215. PMID: 40473608
Invest Ophthalmol Vis Sci

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice. [Abstract]

2025 Jun 2;66(6):13. PMID: 40465266

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (112.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2473 mL

11.2367 mL

22.4734 mL

5 mM

0.4495 mL

2.2473 mL

4.4947 mL

10 mM

0.2247 mL

1.1237 mL

2.2473 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Christopher Chapple, et al. Tamsulosin: an overview. World J Urol. 2002 Apr;19(6):397-404. [Content Brief]

[2]. Rak A, et al. Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity. Bioorg Med Chem. 2016 Nov 1;24(21):5582-5591. [Content Brief]

[3]. Sun L, et al. Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells. Bioengineered. 2021 Dec;12(1):5184-5194. [Content Brief]

[4]. Ida Y, et al. The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner. Bioengineering (Basel). 2022 Oct 14;9(10):556. [Content Brief]

[5]. Youm Y H, et al. Apoptosis Induction and Clusterin Expression of NRP-152 Cells by Tamsulosin. Journal of the Korean Continence Society, 2006, 10(2): 132-139.

[6]. Holanda VAD, et al. Tamsulosin facilitates depressive-like behaviors in mice: Involvement of endogenous glucocorticoids. Brain Res Bull. 2022 Jan;178:29-36. [Content Brief]

[7]. Kim SE, et al. Effects of Tamsulosin on Urinary Bladder Function and Neuronal Activity in the Voiding Centers of Rats with Cyclophosphamide-induced Overactive Bladder. Int Neurourol J. 2012 Mar;16(1):13-22. [Content Brief]

[8]. Alabdali H H, et al. Study the anti-inflammatory effects of tamsulosin by the evaluation of inflammatory cells and lung histopathology in an airway inflammation model in rats. Bulletin of Pharmaceutical Sciences. Assiut, 2023, 46(1): 633-645.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2473 mL	11.2367 mL	22.4734 mL	56.1836 mL
	5 mM	0.4495 mL	2.2473 mL	4.4947 mL	11.2367 mL
	10 mM	0.2247 mL	1.1237 mL	2.2473 mL	5.6184 mL
	15 mM	0.1498 mL	0.7491 mL	1.4982 mL	3.7456 mL
	20 mM	0.1124 mL	0.5618 mL	1.1237 mL	2.8092 mL
	25 mM	0.0899 mL	0.4495 mL	0.8989 mL	2.2473 mL
	30 mM	0.0749 mL	0.3746 mL	0.7491 mL	1.8728 mL
	40 mM	0.0562 mL	0.2809 mL	0.5618 mL	1.4046 mL
	50 mM	0.0449 mL	0.2247 mL	0.4495 mL	1.1237 mL
	60 mM	0.0375 mL	0.1873 mL	0.3746 mL	0.9364 mL
	80 mM	0.0281 mL	0.1405 mL	0.2809 mL	0.7023 mL
	100 mM	0.0225 mL	0.1124 mL	0.2247 mL	0.5618 mL

Tamsulosin hydrochloride

2 Cited Publications

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Tamsulosin hydrochloride

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

GPCR/G Protein Compound Library

Neuronal Signaling Compound Library

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Publications Citing Use of MedChemExpress (MCE) Tamsulosin hydrochloride

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Tamsulosin hydrochloride Related Classifications

HY-B0661A Related Classifications