Atipamezole hydrochloride
Based on 9 publication(s) in Google Scholar
Atipamezole (MPV-1248) hydrochloride is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 104075-48-1
- Formula: C14H17ClN2
- Molecular Weight:248.75
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Atipamezole hydrochloride
More- Protein Cell. 2019 Mar;10(3):178-195. [Abstract]
- Sci Transl Med. 2023 Jan 18;15(679):eabq4064. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116069. [Abstract]
- Front Cell Dev Biol. 2021 Mar 11:9:636327. [Abstract]
- Exp Mol Pathol. 2021 Feb:118:104587. [Abstract]
- Brain Res. 2020 Sep 15:1743:146949. [Abstract]
- Eur J Neurosci. 2021 Apr 27. [Abstract]
- bioRxiv. 2024 November 03.
- Research Square Preprint. 2022 May.
All Adrenergic Receptor Isoforms
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Biological Activity
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α adrenergic receptor |
The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 104075-48-1
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Appearance Solid
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Molecular Weight 248.75
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Formula C14H17ClN2
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Color White to off-white
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SMILES
CCC1(C2=CN=CN2)CC3=C(C=CC=C3)C1.[H]Cl
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Synonyms
MPV-1248 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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Protein Cell
Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy. [Abstract]2019 Mar;10(3):178-195. PMID: 29542010 -
Sci Transl Med
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters. [Abstract]2023 Jan 18;15(679):eabq4064. PMID: 36327352 -
Int Immunopharmacol
Repurposing the anesthetic dexmedetomidine: a novel antidote for sulfur mustard analog-induced acute lung injury via multi-mechanism modulation. [Abstract]2026 Feb 1:170:116069. PMID: 41421231 -
Front Cell Dev Biol
Protective Effects of Dexmedetomidine on the Vascular Endothelial Barrier Function by Inhibiting Mitochondrial Fission via ER/Mitochondria Contact. [Abstract]2021 Mar 11:9:636327. PMID: 33777946 -
Exp Mol Pathol
Up-regulation of miRNA-151-3p enhanced the neuroprotective effect of dexmedetomidine against β-amyloid by targeting DAPK-1 and TP53. [Abstract]2021 Feb:118:104587. PMID: 33275947 -
Brain Res
Blockade of adenosine A1 receptor in nucleus tractus solitarius attenuates baroreflex sensitivity response to dexmedetomidine in rats. [Abstract]2020 Sep 15:1743:146949. PMID: 32522627 -
Eur J Neurosci
Dexmedetomidine protects SH-SY5Y cells against MPP+ -induced declining of mitochondrial membrane potential and cell cycle deficits. [Abstract]2021 Apr 27. PMID: 33905578 -
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Solvent & Solubility
H2O : 75 mg/mL (301.51 mM; Need ultrasonic and warming)
DMSO : ≥ 47 mg/mL (188.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.0201 mL | 20.1005 mL | 40.2010 mL | 100.5025 mL |
| 5 mM | 0.8040 mL | 4.0201 mL | 8.0402 mL | 20.1005 mL | |
| 10 mM | 0.4020 mL | 2.0101 mL | 4.0201 mL | 10.0503 mL | |
| 15 mM | 0.2680 mL | 1.3400 mL | 2.6801 mL | 6.7002 mL | |
| 20 mM | 0.2010 mL | 1.0050 mL | 2.0101 mL | 5.0251 mL | |
| 25 mM | 0.1608 mL | 0.8040 mL | 1.6080 mL | 4.0201 mL | |
| 30 mM | 0.1340 mL | 0.6700 mL | 1.3400 mL | 3.3501 mL | |
| 40 mM | 0.1005 mL | 0.5025 mL | 1.0050 mL | 2.5126 mL | |
| 50 mM | 0.0804 mL | 0.4020 mL | 0.8040 mL | 2.0101 mL | |
| 60 mM | 0.0670 mL | 0.3350 mL | 0.6700 mL | 1.6750 mL | |
| 80 mM | 0.0503 mL | 0.2513 mL | 0.5025 mL | 1.2563 mL | |
| 100 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Atipamezole hydrochloride Related Classifications
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