1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Atipamezole hydrochloride

Atipamezole hydrochloride (Synonyms: MPV-1248 hydrochloride)

Cat. No.: HY-12380 Purity: 99.96%
Handling Instructions

Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

For research use only. We do not sell to patients.

Atipamezole hydrochloride Chemical Structure

Atipamezole hydrochloride Chemical Structure

CAS No. : 104075-48-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 312 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Atipamezole hydrochloride:

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Description

Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

IC50 & Target

Ki: 1.6 nM[1]

In Vitro

The affinity of atipamezole for α2-adrenoceptors and its α21 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].

In Vivo

Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].

Molecular Weight

248.75

Formula

C₁₄H₁₇ClN₂

CAS No.

104075-48-1

SMILES

CCC1(C2=CN=CN2)CC3=C(C=CC=C3)C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 75 mg/mL (301.51 mM; Need ultrasonic and warming)

DMSO : ≥ 47 mg/mL (188.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0201 mL 20.1005 mL 40.2010 mL
5 mM 0.8040 mL 4.0201 mL 8.0402 mL
10 mM 0.4020 mL 2.0101 mL 4.0201 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Product Name:
Atipamezole hydrochloride
Cat. No.:
HY-12380
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