1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Atipamezole

Atipamezole (Synonyms: MPV 1248)

Cat. No.: HY-12380A Purity: 99.48%
Handling Instructions

Atipamezole (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM.

For research use only. We do not sell to patients.

Atipamezole Chemical Structure

Atipamezole Chemical Structure

CAS No. : 104054-27-5

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Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
50 mg USD 312 In-stock
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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Atipamezole:

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Description

Atipamezole (MPV 1248) is a potent α2-adrenoceptor antagonist with a Ki of 1.6 nM[1].

IC50 & Target

Ki: 1.6 nM[1]

In Vitro

The affinity of atipamezole for α2-adrenoceptors and its α21 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

212.29

Formula

C₁₄H₁₆N₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (141.32 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7105 mL 23.5527 mL 47.1054 mL
5 mM 0.9421 mL 4.7105 mL 9.4211 mL
10 mM 0.4711 mL 2.3553 mL 4.7105 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.78 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Atipamezole
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HY-12380A
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