1. GPCR/G Protein Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  2. Adrenergic Receptor ERK
  3. Salbutamol

Salbutamol  (Synonyms: Albuterol; AH-3365)

Cat. No.: HY-B1037 Purity: 99.92%
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Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD).

For research use only. We do not sell to patients.

Salbutamol Chemical Structure

Salbutamol Chemical Structure

CAS No. : 18559-94-9

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Based on 2 publication(s) in Google Scholar

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Description

Salbutamol (Albuterol) is a short-acting beta-2 adrenergic receptor agonist with oral activity. Salbutamol promotes tumorigenesis of gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol is used to study bronchospasms caused by asthma and chronic obstructive pulmonary disease (COPD)[1][2].

IC50 & Target

β adrenergic receptor

 

In Vitro

Salbutamol (16 μM, 24 h) significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MGC803, SGC7901
Concentration: 16 μM
Incubation Time: 24 h
Result: Increased β2-AR and ERK levels.
Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
In Vivo

Salbutamol (5 mg/kg/day, orally, for 2 consecutive weeks) can increase tumor growth in nude mice with gastric cance[1].
Salbutamol (6 mg/kg orally for 4 weeks) has a significant protective effect against STZ (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ induced diabetic rats[2]
Dosage: 6 mg/kg
Administration: p.o. for 4 weeks
Result: Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
Clinical Trial
Molecular Weight

239.31

Formula

C13H21NO3

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(C)(C)C)C1=CC=C(O)C(CO)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (417.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1787 mL 20.8934 mL 41.7868 mL
5 mM 0.8357 mL 4.1787 mL 8.3574 mL
10 mM 0.4179 mL 2.0893 mL 4.1787 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Salbutamol
Cat. No.:
HY-B1037
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