Salbutamol adipate
Based on 6 publication(s) in Google Scholar
Salbutamol (Albuterol) adipate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol adipate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol adipate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.
For research use only. We do not sell to patients.
- CAS No.: 149234-08-2
- Formula: C13H21NO3.1/2C6H10O4
- Molecular Weight:312.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Salbutamol adipate
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In Vivo Efficacy Study
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All Adrenergic Receptor Isoforms
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Biological Activity
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β adrenergic receptor |
Salbutamol (16 μM; 24 h) adipate significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC803, SGC7901
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Concentration:16 μM
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Incubation Time:24 h
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Result:Increased β2-AR and ERK levels.
Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).
Salbutamol (6 mg/kg; oral administration; 4 weeks) adipate has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Streptozotocin induced diabetic rats[2]
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Dosage:6 mg/kg
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Administration:Oral administration (p.o.); 4 weeks
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Result:Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.
Chemical Information
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CAS No. 149234-08-2
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Molecular Weight 312.38
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Formula C13H21NO3.1/2C6H10O4
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SMILES
O=C(CCCCC(O)=O)O.OC1=CC=C(C(CNC(C)(C)C)O)C=C1CO.[1/2]
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Synonyms
Albuterol adipate; AH-3365 adipate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]2024 Nov;11(41):e2402393. PMID: 39229959
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.
Salbutamol adipate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Nov;11(41):e2402393. [Abstract]
Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.
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Chin Med J (Engl)
Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment. [Abstract]2026 Apr 23. PMID: 42036893 -
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Anal Chem
2025 Jul 15;97(27):14220-14229. PMID: 40601392 -
Respir Res
Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. [Abstract]2022 Dec 28;23(1):380. PMID: 36575527 -
Mol Biol Rep
Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]2026 Feb 26;53(1):434. PMID: 41746444
Purity & Documentation
References
[1]. Lu Y, et al. Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through β2-AR/ERK/EMT pathway. J Cancer. 2022 Jan 1;13(2):401-412. [Content Brief]
[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Salbutamol adipate Related Classifications
HY-B1037B Related Classifications
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