2. Metabolic Enzyme/Protease GPCR/G Protein Neuronal Signaling Anti-infection
  3. Drug Metabolite Adrenergic Receptor Antibiotic
  4. Terbutaline

Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol. Terbutaline can be used in asthma symptom research.

For research use only. We do not sell to patients.

Terbutaline

Terbutaline Chemical Structure

CAS No. : 23031-25-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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25 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Terbutaline:

Terbutaline Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Terbutaline

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α adrenergic receptor β adrenergic receptor

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Terbutaline is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol[1]. Terbutaline can be used in asthma symptom research[2].

IC50 & Target

Beta-2 adrenergic receptor

 

In Vitro

Terbutaline (0-10 μM, 1 hour) enhances MKP-1 expression in activated mouse macrophages[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Terbutaline Related Antibodies

RT-PCR[3]

Cell Line: J774 macrophages
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Enhanced MKP-1 expression in J774 macrophages in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line: J774 macrophages
Concentration: 100 nM
Incubation Time: 1 hour
Result: Reduced the phosphorylation of p38 MAPK in J774 macrophages.
In Vivo

Terbutaline (intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days) treatment can improve the allodynia in ob/ob mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male ob/ob mice[4]
Dosage: 0.5 mg/kg
Administration: Intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days
Result: Reversed the mechanical allodynia in ob/ob mice.
Molecular Weight

225.28

Formula

C12H19NO3
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

OC1=CC(C(O)CNC(C)(C)C)=CC(O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (887.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4389 mL 22.1946 mL 44.3892 mL
5 mM 0.8878 mL 4.4389 mL 8.8778 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (22.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (22.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.94%

SDS (393 KB)

COA (246 KB) HNMR (138 KB) RP-HPLC (140 KB) LCMS (235 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4389 mL 22.1946 mL 44.3892 mL 110.9730 mL
5 mM 0.8878 mL 4.4389 mL 8.8778 mL 22.1946 mL
10 mM 0.4439 mL 2.2195 mL 4.4389 mL 11.0973 mL
15 mM 0.2959 mL 1.4796 mL 2.9593 mL 7.3982 mL
20 mM 0.2219 mL 1.1097 mL 2.2195 mL 5.5487 mL
25 mM 0.1776 mL 0.8878 mL 1.7756 mL 4.4389 mL
30 mM 0.1480 mL 0.7398 mL 1.4796 mL 3.6991 mL
40 mM 0.1110 mL 0.5549 mL 1.1097 mL 2.7743 mL
50 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2195 mL
60 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8496 mL
80 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
100 mM 0.0444 mL 0.2219 mL 0.4439 mL 1.1097 mL
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Terbutaline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terbutaline23031-25-6Drug MetaboliteAdrenergic ReceptorAntibioticBeta ReceptorasthmamacrophagesMPK-1J774 macrophagesInhibitorinhibitorinhibit

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