1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Terbutaline sulfate

Terbutaline sulfate (Synonyms: Terbutaline hemisulfate)

Cat. No.: HY-B0802 Purity: 99.83%
Handling Instructions

Terbutaline sulfate is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol. Terbutaline sulfate can be used in asthma symptom research.

For research use only. We do not sell to patients.

Terbutaline sulfate Chemical Structure

Terbutaline sulfate Chemical Structure

CAS No. : 23031-32-5

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
Solid
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
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5 g USD 240 In-stock
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Description

Terbutaline sulfate is an orally active β2-adrenergic receptor agonist and an active metabolite of bambuterol[1]. Terbutaline sulfate can be used in asthma symptom research[2].

In Vitro

Terbutaline sulfate (0-10 μM, 1 hour) enhances MKP-1 expression in activated mouse macrophages[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[3]

Cell Line: J774 macrophages
Concentration: 0-10 μM
Incubation Time: 1 hour
Result: Enhanced MKP-1 expression in J774 macrophages in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line: J774 macrophages
Concentration: 100 nM
Incubation Time: 1 hour
Result: Reduced the phosphorylation of p38 MAPK in J774 macrophages.
In Vivo

Terbutaline sulfate (intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days) treatment can improve the allodynia in ob/ob mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male ob/ob mice[4]
Dosage: 0.5 mg/kg
Administration: Intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days
Result: Reversed the mechanical allodynia in ob/ob mice.
Clinical Trial
Molecular Weight

274.32

Formula

C12H20NO5S0.5

CAS No.
SMILES

OC1=CC(C(O)CNC(C)(C)C)=CC(O)=C1.[0.5H2SO4]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (911.34 mM; Need ultrasonic)

DMSO : 5 mg/mL (18.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6454 mL 18.2269 mL 36.4538 mL
5 mM 0.7291 mL 3.6454 mL 7.2908 mL
10 mM 0.3645 mL 1.8227 mL 3.6454 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 120 mg/mL (437.45 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.82 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.82 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.82 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.83%

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Terbutaline sulfate
Cat. No.:
HY-B0802
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