Cat. No.: HY-B0802

Terbutaline sulfate

(Synonyms: Terbutaline hemisulfate)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Terbutaline sulfate is an orally active β₂-adrenergic receptor agonist and an active metabolite of bambuterol. Terbutaline sulfate can be used in asthma symptom research.

For research use only. We do not sell to patients.

Purity: 99.95%
CAS No.: 23031-32-5
Formula: C₁₂H₂₀NO₅S_0.5
Molecular Weight:274.32

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Terbutaline sulfate Chemical Structure

CAS No.: 23031-32-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Terbutaline sulfate is an orally active β₂-adrenergic receptor agonist and an active metabolite of bambuterol^[1]. Terbutaline sulfate can be used in asthma symptom research^[2].

IC₅₀ & Target

β adrenergic receptor

All Adrenergic Receptor Isoforms :

All Antibiotic Isoforms :

In Vitro

Terbutaline sulfate (0-10 μM, 1 hour) enhances MKP-1 expression in activated mouse macrophages^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[3]

Cell Line:

J774 macrophages
Concentration:

0-10 μM
Incubation Time:

1 hour
Result:

Enhanced MKP-1 expression in J774 macrophages in a dose-dependent manner.

Western Blot Analysis^[3]

Cell Line:

J774 macrophages
Concentration:

100 nM
Incubation Time:

1 hour
Result:

Reduced the phosphorylation of p38 MAPK in J774 macrophages.

In Vivo

Terbutaline sulfate (intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days) treatment can improve the allodynia in ob/ob mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult male ob/ob mice^[4]
Dosage:

0.5 mg/kg
Administration:

Intraperitoneal injection; 0.5 mg/kg; twice a day; 20 days
Result:

Reversed the mechanical allodynia in ob/ob mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 23031-32-5
Appearance Solid
Molecular Weight 274.32
Formula C₁₂H₂₀NO₅S_0.5
Color White to off-white
SMILES

O=S(O)(O)=O.OC1=CC(C(O)CNC(C)(C)C)=CC(O)=C1
Synonyms

Terbutaline hemisulfate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Aging Cell

Aerobic Exercise Attenuates Autophagy-Lysosomal Flux Deficits via β2-AR-Mediated ESCRT-III Subunit CHMP4B in Mice With Human MAPT P301L. [Abstract]

2025 Jul 26:e70184. PMID: 40715737

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (182.27 mM; Need ultrasonic)

DMSO : 5 mg/mL (18.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6454 mL

18.2269 mL

36.4538 mL

5 mM

0.7291 mL

3.6454 mL

7.2908 mL

10 mM

0.3645 mL

1.8227 mL

3.6454 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.5 mg/mL (1.82 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 0.5 mg/mL (1.82 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 0.5 mg/mL (1.82 mM); Clear solution

This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 120 mg/mL (437.45 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohamed Ismail NA, et al. Nifedipine versus terbutaline for tocolysis in external cephalic version. Int J Gynaecol Obstet. 2008 Sep;102(3):263-6. [Content Brief]

[2]. Joana A Loureiro, et al. The interaction of a β2 adrenoceptor agonist drug with biomimetic cell membrane models: The case of terbutaline sulphate. Life Sci. 2021 Nov 15;285:119992. [Content Brief]

[3]. Tiina Keränen, et al. Anti-Inflammatory Effects of β2-Receptor Agonists Salbutamol and Terbutaline Are Mediated by MKP-1. PLoS One. 2016 Feb 5;11(2):e0148144. [Content Brief]

[4]. Nada Choucair-Jaafar, et al. The antiallodynic action of nortriptyline and terbutaline is mediated by β(2) adrenoceptors and δ opioid receptors in the ob/ob model of diabetic polyneuropathy. Brain Res. 2014 Feb 10;1546:18-26. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.6454 mL	18.2269 mL	36.4538 mL	91.1344 mL
	5 mM	0.7291 mL	3.6454 mL	7.2908 mL	18.2269 mL
	10 mM	0.3645 mL	1.8227 mL	3.6454 mL	9.1134 mL
	15 mM	0.2430 mL	1.2151 mL	2.4303 mL	6.0756 mL
H₂O	20 mM	0.1823 mL	0.9113 mL	1.8227 mL	4.5567 mL
	25 mM	0.1458 mL	0.7291 mL	1.4582 mL	3.6454 mL
	30 mM	0.1215 mL	0.6076 mL	1.2151 mL	3.0378 mL
	40 mM	0.0911 mL	0.4557 mL	0.9113 mL	2.2784 mL
	50 mM	0.0729 mL	0.3645 mL	0.7291 mL	1.8227 mL
	60 mM	0.0608 mL	0.3038 mL	0.6076 mL	1.5189 mL
	80 mM	0.0456 mL	0.2278 mL	0.4557 mL	1.1392 mL
	100 mM	0.0365 mL	0.1823 mL	0.3645 mL	0.9113 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Terbutaline sulfate

1 Cited Publications

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Terbutaline sulfate

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Publications Citing Use of MedChemExpress (MCE) Terbutaline sulfate

All Adrenergic Receptor Isoforms

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Terbutaline sulfate Related Classifications

HY-B0802 Related Classifications