1. GPCR/G Protein
    Anti-infection
    Metabolic Enzyme/Protease
  2. Glucocorticoid Receptor
    Enterovirus
    Endogenous Metabolite
  3. Fluticasone (propionate)

Fluticasone (propionate) 

Cat. No.: HY-B0154 Purity: 99.97%
Handling Instructions

Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity.

For research use only. We do not sell to patients.

Fluticasone (propionate) Chemical Structure

Fluticasone (propionate) Chemical Structure

CAS No. : 80474-14-2

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10 mM * 1 mL in DMSO USD 99 In-stock
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10 mg USD 90 In-stock
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50 mg USD 270 In-stock
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Description

Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Fluticasone propionate inhibits TNFα-induced E-selectin expression, with an IC50 of 1 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

500.57

Formula

C₂₅H₃₁F₃O₅S

CAS No.

80474-14-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (199.77 mM; Need ultrasonic)

H2O : 1 mg/mL (2.00 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9977 mL 9.9886 mL 19.9772 mL
5 mM 0.3995 mL 1.9977 mL 3.9954 mL
10 mM 0.1998 mL 0.9989 mL 1.9977 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Fluticasone (propionate)Glucocorticoid ReceptorEnterovirusEndogenous MetaboliteRhinovirusHRVHRVsHEVHEVsanti-inflammatorycorticosteroid seasonalallergicperennialrhinitisbronchialasthmaInhibitorinhibitorinhibit

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Fluticasone (propionate)
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HY-B0154
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