1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Fluticasone propionate

Fluticasone propionate 

Cat. No.: HY-B0154 Purity: 99.97%
Handling Instructions

Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.

For research use only. We do not sell to patients.

Fluticasone propionate Chemical Structure

Fluticasone propionate Chemical Structure

CAS No. : 80474-14-2

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10 mM * 1 mL in DMSO USD 99 In-stock
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Description

Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis. Target: Glucocorticoid Receptor Fluticasone propionate is a corticosteroid derived from fluticasone used to treat asthma and allergic rhinitis. It is also used to treat eosinophilic esophagitis. Fluticasone propionate is a synthetic trifluorinated glucocorticoid. It is highly lipophilic (logp octanol/water 3.69). In studies the topical drug has been associated with burning, stinging, skin irritation, blisters, dryness, skin infection, infected eczema, viral warts,impetigo, atopic dermatitis, pruritus, exacerbation of pruritus, exacerbation of eczema, erythema, and folliculitis. There are also numerous side effects associated with the oral version of this medication including headache, stuffy or runny nose, difficulty speaking, sore or irritated throat and painful white patches in the mouth or throat. Candidiasis of mouth and throat is reported as a "very common" side effect indicating that it occurs with a frequency greater than 1 in 10.Hoarseness is "common" indicating a frequency from 1 in 10 to 1 in 100. In both instances rinsing the mouth with water immediately after inhalation is recommended.

Molecular Weight

500.57

Formula

C₂₅H₃₁F₃O₅S

CAS No.

80474-14-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (499.43 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9977 mL 9.9886 mL 19.9772 mL
5 mM 0.3995 mL 1.9977 mL 3.9954 mL
10 mM 0.1998 mL 0.9989 mL 1.9977 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.97%

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Fluticasone propionate
Cat. No.:
HY-B0154
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