1. Stem Cell/Wnt
    Immunology/Inflammation
  2. Smo
    Glucocorticoid Receptor
  3. Fluticasone

Fluticasone 

Cat. No.: HY-B0603
Handling Instructions

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells.

For research use only. We do not sell to patients.

Fluticasone Chemical Structure

Fluticasone Chemical Structure

CAS No. : 90566-53-3

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Description

Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].

In Vitro

Fluticasone (0-10 μM, 2 h) inhibits U2OS cells growth with an EC50 value of 99 nM[2].
Fluticasone (10-1000 nM, 48 h) decreases HRV-induced mucin production and involves in modulation of SPDEF-regulated genes and extracellular ATP release[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fluticasone (1 mg/kg; intranasal dropping; 7 d) suppresses rhinovirus-induced airways inflammation in vivo but also impairs anti-viral immune responses and increases viral titres, leading to mucus hypersecretion[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[4]
Dosage: 1 mg/kg
Administration: Intranasal dropping; 1 h before infection with rhinovirus 1B; 7 days
Result: Suppressed BAL neutrophil numbers and inhibited rhinovirus-induced airway inflammation.
Molecular Weight

444.51

Formula

C22H27F3O4S

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Fluticasone
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