90566-53-3
Chemical Structure
Fluticasone
- CAS No.: 90566-53-3
- Formula:C22H27F3O4S
- Molecular Weight:444.51
IUPAC Name: S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbothioate
InChIKey: MGNNYOODZCAHBA-GQKYHHCASA-N
SMILES: C[C@]([C@](O)1C(SCF)=O)(C[C@@H]2O)[C@](C[C@H]1C)([H])[C@@](C[C@@H]3F)([H])[C@]2([C@](C3=CC4=O)(C=C4)C)F
Biological Activity: Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells[1][2].
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Fluticasone | 98.70% | Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells. | ||||||||||||||||||||
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Fluticasone (Standard) | ≥98% | Fluticasone (Standard) is the analytical standard of Fluticasone. This product is intended for research and analytical applications. Fluticasone is an inhaled corticosteroid used for respiratory research. Fluticasone is a Smo agonist with an IC50 value of 99 nM. Fluticasone activates Hedgehog signaling and promotes the proliferation of primary neuronal stem or precursor cells. | ||||||||||||||||||||
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References
- [1]. Seidel P, et al. Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies. Respir Res. 2012 Oct 4. 13(1):90. [Content Brief]
- [2]. Wang J, et al. Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18. 107(20):9323-8. [Content Brief]
