80474-14-2
Chemical Structure
Fluticasone propionate
- CAS No.: 80474-14-2
- Formula:C25H31F3O5S
- Molecular Weight:500.57
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
InChIKey: WMWTYOKRWGGJOA-CENSZEJFSA-N
SMILES: O=C(O[C@@]1(C(SCF)=O)[C@](C[C@@H]([C@]([C@@]2(C)C=CC3=O)([C@]4(C[C@@H](C2=C3)F)[H])F)O)(C)[C@]4(C[C@H]1C)[H])CC
Biological Activity: Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity[1][2].
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Fluticasone propionate | 99.93% | Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity. | ||||||||||||||||||||
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Fluticasone propionate (Standard) | ≥98% | Fluticasone propionate (Standard) is the analytical standard of Fluticasone propionate. This product is intended for research and analytical applications. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity. | ||||||||||||||||||||
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Fluticasone propionate-d5 | Fluticasone propionate-d5 is deuterium labeled Fluticasone (propionate). Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity. | |||||||||||||||||||||
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Fluticasone propionate-d3 | 95.22% | Fluticasone propionate-d3 is the deuterium labeled Fluticasone propionate. Fluticasone propionate, a potent topical anti-inflammatory corticosteroid, is a selective glucocorticoid receptor agonist, with an absolute affinity (KD) of 0.5 nM. Fluticasone propionate shows little or no activity at other steroid receptors. Anti-viral activity. | ||||||||||||||||||||
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Similarity Score 0.92
HY-Z7966Fluticasone impurity 7 -
Similarity Score 0.92
HY-105818Cloticasone propionate -
Similarity Score 0.91
HY-Z7967Fluticasone impurity 8 -
Similarity Score 0.88
HY-Z7965Fluticasone impurity 1 -
Similarity Score 0.87
HY-W776953R6a,9a-Difluoro-11b-hydroxy-16a-methyl-3-oxo-17a-(propionyloxy)-androsta-1,4-diene-17b-carbothioic Acid (Standard) -
Similarity Score 0.86
HY-180954Fluticasone propionate-C-S-CH3 -
Similarity Score 0.82
HY-Z7968Fluticasone impurity 9 -
Similarity Score 0.82
HY-B0878Halobetasol propionate -
Similarity Score 0.82
HY-Z7964Fluticasone impurity 6 -
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References
- [1]. Bryson HM, et al. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in allergic rhinitis. Drugs. 1992;43(5):760-775. [Content Brief]
- [2]. Johnson M. The anti-inflammatory profile of fluticasone propionate. Allergy. 1995;50(23 Suppl):11-14. [Content Brief]
