1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. Fluticasone furoate

Fluticasone furoate 

Cat. No.: HY-15234 Purity: 99.06%
Handling Instructions

Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.

For research use only. We do not sell to patients.

Fluticasone furoate Chemical Structure

Fluticasone furoate Chemical Structure

CAS No. : 397864-44-7

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10 mM * 1 mL in DMSO USD 61 In-stock
Estimated Time of Arrival: December 31
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment[1][2].

IC50 & Target

Kd: 0.3 nM (Corticosteroid)[1]

In Vitro

Fluticasone furoate comes in a nasal spray, as an aqueous suspension of micronized fluticasone furoate for topical administration to the nasal mucosa by means of a metering, atomizing spray pump[1].
Fluticasone furonate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furonate is also potent in preventing damage to cultured human lung epithelial cells by different stimulus[1].

In Vivo

Fluticasone furonate is 99.4% bound to plasma protein in vitro and other research indicated extensive first-pass metabolism of the absorbed drug. Protein binding is highly relevant because only the unbound free drug can exert an effect at the receptor site. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme (CYP) 3A4 that converts the drug to the 17β-carboxylic acid metabolite (M10), which displays low glucocorticoid receptor agonist potency. Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine[1].

Molecular Weight

538.58

Formula

C₂₇H₂₉F₃O₆S

CAS No.

397864-44-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (464.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8567 mL 9.2837 mL 18.5673 mL
5 mM 0.3713 mL 1.8567 mL 3.7135 mL
10 mM 0.1857 mL 0.9284 mL 1.8567 mL
*Please refer to the solubility information to select the appropriate solvent.
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Keywords:

Fluticasone furoateGlucocorticoid ReceptorAnti-inflamatoryfluorinatedcorticosteroidintranasalallergicrhinitislipophilicCYP3A4anti-asthmaticInhibitorinhibitorinhibit

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Fluticasone furoate
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HY-15234
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