Fluticasone furoate-d5
Based on 1 Customer Validation
Fluticasone furoate-d5 is deuterium-labeled Fluticasone furoate (HY-15234).
For research use only. We do not sell to patients.
- Purity: 99.65%
- Formula: C27H24D5F3O6S
- Molecular Weight:543.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable or radioisotope-labeled compounds allow precise tracking and quantification of individual atoms in metabolic pathways. Stable isotopes generally do not change molecular properties but may slightly affect metabolic kinetics; radioactive isotopes may interfere with cells. Markers can distinguish endogenous and exogenous metabolites, reduce false positives, and are beneficial to quantification and reconstruction of metabolic pathways[2].
In cell culture or enzymatic reactions, the use of isotope markers can precisely control the concentration and exposure time, making it easy to study metabolic reactions and enzyme activities. Through stable isotope analytical metabolomics (SIRM), cellular metabolic networks can be studied, key metabolic nodes and regulatory mechanisms can be identified, and targets can be provided for compound development.
Isotope-labeled compounds can be used in competition binding experiments to evaluate the affinity and binding kinetics of compounds to receptors to help optimize design. Stable isotope labels are used as internal standards in mass spectrometry analysis to improve analysis accuracy and reproducibility and reduce matrix effect interference[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 397864-44-7
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Appearance Solid
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Molecular Weight 543.61
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Formula C27H24D5F3O6S
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Color White to off-white
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SMILES
O=C(C1=C([2H])C([2H])=C([2H])O1)O[C@]2([C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C([C@H](C4)F)=CC(C=C5)=O)C)F)([H])C[C@H]2C)C)C(SC([2H])([2H])F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (183.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3]. Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8396 mL | 9.1978 mL | 18.3955 mL | 45.9889 mL |
| 5 mM | 0.3679 mL | 1.8396 mL | 3.6791 mL | 9.1978 mL | |
| 10 mM | 0.1840 mL | 0.9198 mL | 1.8396 mL | 4.5989 mL | |
| 15 mM | 0.1226 mL | 0.6132 mL | 1.2264 mL | 3.0659 mL | |
| 20 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2994 mL | |
| 25 mM | 0.0736 mL | 0.3679 mL | 0.7358 mL | 1.8396 mL | |
| 30 mM | 0.0613 mL | 0.3066 mL | 0.6132 mL | 1.5330 mL | |
| 40 mM | 0.0460 mL | 0.2299 mL | 0.4599 mL | 1.1497 mL | |
| 50 mM | 0.0368 mL | 0.1840 mL | 0.3679 mL | 0.9198 mL | |
| 60 mM | 0.0307 mL | 0.1533 mL | 0.3066 mL | 0.7665 mL | |
| 80 mM | 0.0230 mL | 0.1150 mL | 0.2299 mL | 0.5749 mL | |
| 100 mM | 0.0184 mL | 0.0920 mL | 0.1840 mL | 0.4599 mL |
Fluticasone furoate-d5 Related Classifications
HY-15234S1 Related Classifications
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