1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Prazosin

Prazosin 

Cat. No.: HY-B0193
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Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder.

For research use only. We do not sell to patients.

Prazosin Chemical Structure

Prazosin Chemical Structure

CAS No. : 19216-56-9

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Top Publications Citing Use of Products

    Prazosin purchased from MCE. Usage Cited in: Biomed Pharmacother. 2020 Apr;124:109731.

    The expression of TNS1 in U937 and HL60 cells treated with different concentration of Prazosin is detected by Western blot analysis
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    Description

    Prazosin is an alpha-adrenergic blocker and is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, and panic disorder. Target: Adrenergic Receptor Prazosin, is a sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. It is an alpha-adrenergic blocker that is specific for the alpha-1 receptors. These receptors are found on vascular smooth muscle, where they are responsible for the vasoconstrictive action of norepinephrine. They are also found throughout the central nervous system. As of 2013, prazosin is off-patent in the US, and the FDA has approved at least one generic manufacturer.In addition to its alpha-blocking activity, prazosin is an antagonist of the MT3 receptor (which is not present in humans), with selectivity for this receptor over the MT1 and MT2 receptors. Prazosin is orally active and has a minimal effect on cardiac function due to its alpha-1 receptor selectivity. However, when prazosin is initially started, heart rate and contractility go up in order to maintain the pre-treatment blood pressures because the body has reached homeostasis at its abnormally high blood pressure. The blood pressure lowering effect becomes apparent when prazosin is taken for longer periods of time. The heart rate and contractility go back down over time and blood pressure decreases.

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    Molecular Weight

    383.40

    Formula

    C₁₉H₂₁N₅O₄

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    Please store the product under the recommended conditions in the Certificate of Analysis.

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